摘要
动脉粥样硬化性心血管疾病(atherosclerotic cardiovascular disease,ASCVD)作为心血管病中以动脉粥样硬化为病理基础的一系列疾病的总称,其发病风险得到临床越来越多的关注。然而,随着人群研究数据的增加,传统血脂指标如低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)的诊疗价值显示出局限性。近年有大量研究证实小而密低密度脂蛋白胆固醇(small dense low-density lipoprotein-cholesterol,sdLDL-C)与低密度脂蛋白受体的亲和力更低、有更长的循环时间、更容易穿透动脉内皮等特点,所以具备更强的致动脉粥样硬化作用。因此本文阐述了sdLDL-C的常用检测方法、sdLDL-C与ASCVD风险相关性的研究进展,以及sdLDL-C水平的干预措施和影响因素,旨在加深临床医生对sdLDL-C在ASCVD中作用的认识,达到对动脉粥样硬化慢病的早预防、早发现、早诊断。
Atherosclerotic cardiovascular disease(ASCVD),a series of cardiovascular diseases based on atherosclerosis,has attracted more clinical attention.However,with the increase of population-based research results,the diagnostic value of traditional blood lipid parameters such as low density lipoprotein-cholesterol(LDL-C)is showing limitations.In recent years,a large number of studies have confirmed that small dense low-density lipoprotein cholesterol(sdLDL-C)has lower affinity with low-density lipoprotein receptor,longer circulation time and easier to penetrate arterial endothelium,so it has stronger atherogenic effect.Therefore,we summarize the common detection methods of sdLDL-C,the research progress of the correlation between sdLDL-C and ASCVD risk,as well as the intervention measures and influencing factors of sdLDL-C level,in order to deepen the clinician′s understanding of the role of sdLDL-C in ASCVD and achieve the early prevention,early detection and early diagnosis of chronic atherosclerosis.
作者
范雪松
莘琳琳
胡荣
贺建勋
李源泰
袁慧
Fan Xuesong;Sheri Linlin;Hu Rong;He Jianxun;Li Yuantai;Yuan Hui(Department of Clinical Laboratory,Beijing Anzhen Hospital,Beijing 100029,China;Graduate School,Capital Medical University,Beijing 100069,China;Department of Laboratory Medicine,Capital Medical University,Beijing 100069,China)
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2021年第12期1507-1512,共6页
Chinese Journal of Preventive Medicine
基金
吴阶平医学基金(320.6750.2021-06-1)。
