摘要
分析业余马拉松运动员竞赛前后乳酸脱氢酶、肌酸激酶、肌酸激酶同工酶、高敏肌钙蛋白T、N末端B型钠尿肽前体、同型半胱氨酸及新型炎症指标(中性粒细胞-淋巴细胞比值、血小板-淋巴细胞比值、全身免疫炎症指数)的变化,评估急性运动导致的心肌损伤及新型炎症指标在马拉松运动监测中的应用价值。本文为分析性研究。选择北京医院招募的分别参加2022年北京马拉松和2023年天津马拉松的业余运动员和2023年1—6月于北京医院体检中心健康体检人群作为研究对象,依照纳入标准入选业余马拉松运动员65名(男性41名,女性24名),健康对照人群130名(男性82名,女性48名)。业余马拉松运动员分别在跑前1周、跑后即刻及跑后1周采集外周血,检测或计算上述指标。采用Wilcoxon符号秩检验及Spearman等级相关分析,比较业余马拉松人群与健康体检人群之间各指标水平的差异,同时比较业余马拉松运动员3个时间点各指标的变化及相关关系。结果显示健康体检人群和业余马拉松运动员跑前1周的中性粒细胞-淋巴细胞比值为1.73(1.33,2.16)、1.67(1.21,2.16),血小板-淋巴细胞比值为122.75(96.69,155.89)、120.86(100.74,154.63),全身免疫炎症指数为398.62(274.50,538.69)、338.41(258.62,485.38)等;业余马拉松运动员在跑前1周、跑后即刻及跑后1周的乳酸脱氢酶为173.00(159.00,196.50)U/L、284.00(237.50,310.50)U/L、183.00(165.50,206.50)U/L,肌酸激酶为131.00(94.30,188.20)U/L、318.00(212.00,573.15)U/L、139.00(90.55,202.40)U/L,肌酸激酶同工酶为2.50(1.76,3.43)μg/L、6.24(4.87,10.30)μg/L、2.73(1.57,4.40)μg/L等。65名业余马拉松运动员中,跑后即刻与跑前1周相比,乳酸脱氢酶、肌酸激酶、肌酸激酶同工酶、高敏肌钙蛋白T、N末端B型钠尿肽前体、同型半胱氨酸及新型炎症指标均显著升高,差异有统计学意义(Z=-7.009,Z=-6.813,Z=-6.885,Z=-7.009,Z=-7.009,Z=-6.656;以上指标
To analyze the changes in lactate dehydrogenase,creatine kinase,creatine kinase isoenzyme,high-sensitivity troponin T,N-terminal B-type natriuretic peptide precursor,homocysteine,and novel inflammatory indices(neutrophil-lymphocyte ratio,platelet-lymphocyte ratio,systemic immune-inflammation index)before and after competitions in amateur marathon runners,and to assess the effects of myocardial injury due to acute exercise and the value of novel inflammatory indices in marathon exercise monitoring.This paper is an analytical study.Amateur athletes recruited by Beijing Hospital to participate in the 2022 Beijing Marathon and the 2023 Tianjin Marathon,and those who underwent health checkups at the Beijing Hospital Medical Checkup Center from January to June 2023 were selected as the study subjects,and 65 amateur marathon runners(41 males and 24 females)and 130 healthy controls(82 males and 48 females)were enrolled in the study according to the inclusion criteria.Peripheral blood was collected one week before,immediately after,and one week after running,and routine blood tests,cardiac enzymes,infarction markers,N-terminal B-type natriuretic peptide precursor,and homocysteine were performed to calculate the values of novel inflammatory indexes.Wilcoxon signed-rank test and Spearman′s rank correlation analysis were used to compare the differences in the levels of each index between the amateur marathon population and the health checkup population,and to compare the changes and correlations of each index at the three time points in the amateur marathoners.The results showed that the neutrophil-lymphocyte ratios of the healthy physical examination population and 65 amateur marathoners 1 week before running were 1.73(1.33,2.16)and 1.67(1.21,2.16),the platelet-lymphocyte ratios were 122.75(96.69,155.89)and 120.86(100.74,154.63),and the systemic immune inflammation index was 398.62(274.50,538.69)and 338.41(258.62,485.38),etc.;on 1 week before running,immediately after running and 1 week after running,lactate dehydrogenase
作者
王泉儿
赵敏迪
袁婷婷
步霄霄
汪芳
李传保
Wang Quaner;Zhao Mindi;Yuan Tingting;Bu Xiaoxiao;Wang Fang;Li Chuanbao(Department of Labratory Medicine,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Cardiology,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China)
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2024年第8期1230-1235,共6页
Chinese Journal of Preventive Medicine
基金
中央高水平医院临床科研业务费(BJ-2022-094,BJ-2023-202)。
关键词
马拉松
新型炎症指标
心肌损伤
运动监测
Marathon
Novel inflammatory indicators
Myocardial injury
Exercise monitoring
