摘要
心血管疾病严重威胁人类健康,已成为全球首要死因,早诊早治意义重大。微流控技术因其微型化、集成化、易操作等特点为心血管疾病标志物的快速、多靶标检测提供可选方案,极大的推动了心血管疾病的快速诊断。本文阐述微流控技术在心血管疾病诊断及预防中的研究进展,分析其在蛋白质类、脂质类、核酸类生物标志物快速检测中的优势与不足,以期为推动心血管疾病快速检测技术发展提供参考,为心血管疾病的早期防治提供新思考。
Cardiovascular disease is a major threat to human health and has become the leading cause of death worldwide;therefore,early diagnosis and treatment are of great value.Due to its miniaturization,integration,and ease of operation,microfluidic technology enables the rapid,multi-target detection of cardiovascular disease markers and significantly facilitates the early and rapid diagnosis of cardiovascular disease.This article reviews the research progress of microfluidics in cardiovascular disease detection,analyzes its advantages and weaknesses in the rapid detection of protein,lipid,and nucleic acid biomarkers,hopes to provide a reference to promote the quick detection technology of cardiovascular disease,and thus proposes new considerations for the early management of cardiovascular disease.
作者
陈太菊
刘睿宁
张洪
牟华明
罗阳
Chen Taiju;Liu Ruining;Zhang Hong;Mou Huaming;Luo Yang(Center for Intelligent Laboratory and Molecular Medicine,School of Medicine Chongqing University,Chongqing 400030,China;Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission,Chongqing 400020,China;Laboratory Medicine Center of the Second Hospital of Shandong University,Jinan 250033,China;Department of Cardiovascular Medicine,Three Gorges Hospital Affiliated to Chongqing University,Chongqing 404100,China)
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2023年第7期1115-1123,共9页
Chinese Journal of Preventive Medicine
基金
国家杰出青年科学基金(82125022)
中国博士后科学基金资助(BX20220194)
重庆市高等教育教学改革研究项目(213035)。
关键词
微流控
心血管疾病
生物标志物
蛋白质检测
即时检测
Microfluidics
Cardiovascular disease
Biomarkers
Protein detection
Point-of-care testing
