摘要
目的检测腺病毒肺炎患儿的血液指标、T淋巴细胞亚群及病毒分型,为临床诊治腺病毒肺炎患儿提供参考。方法选取2018年6月—2020年3月在江西省儿童医院呼吸内科住院并诊断为腺病毒肺炎的60例患儿为研究对象,按病情分为重症组(30例)和非重症组(30例)。比较两组患儿的血液指标、C-反应蛋白(CRP)和降钙素原(PCT)水平,T淋巴细胞亚群。结果重症组患儿中性粒细胞、CRP、PCT及CD8^(+)T淋巴细胞水平分别为(6.35±2.22)×10^(9)/L、(28.15±7.43)mg/L、(17.32±7.85)ng/ml及(31.34±4.12)%,显著高于非重症组患儿[(4.42±1.23)×10^(9)/L、(12.56±6.42)mg/L、(1.34±3.46)ng/ml及(23.21±2.33)%],差异均有统计学意义(t=3.324、5.435、16.689及3.494,均P<0.05)。重症组患儿血小板、CD4^(+)T淋巴细胞、CD4^(+)/CD8^(+)T淋巴细胞比值及NK细胞水平分别为(124.00±73.00)×10^(9)/L、(26.63±6.23)%、(0.96±0.23)%及(10.23±4.11)%,均显著低于非重症组患儿[(302.00±96.00)×10^(9)/L、(33.43±5.62)%、(1.25±0.49)%及(19.83±6.35)%],差异均有统计学意义(t=2.543、3.745、5.243及2.341,均P<0.05)。3型组和7型组患儿的非重症/重症比例、CRP及PCT水平比较差异均有统计学意义(均P<0.05)。结论对于早期检测出腺病毒肺炎的患儿,如炎症指标水平高或免疫功能下降,提示有患重症腺病毒肺炎的可能,需警惕7型的可能性。
Objective To detect blood indicators,T lymphocyte subgroups,and viral typing in children with adenoviral pneumonia,provide reference for clinical diagnosis and treatment of adenoviral pneumonia in children.Methods From June 2018 to March,60 children diagnosed as adenoviral pneumonia and treated in Department of Respiratory Medicine,Jiangxi Provincial Children’s Hospital were selected and divided into severe group and non-severe group according to severity of the disease,30 children in each group.The levels of blood indicators,C-reactive protein(CRP),and procalcitonin(PCT),and T lymphocyte subgroups in the two groups were compared.Results The levels of neutrophils,CRP,PCT,and CD8^(+)T lymphocyte in severe group were(6.35±2.22)×10^(9)/L,(28.15±7.43)mg/L,(17.32±7.85)ng/ml,and(31.34±4.12)%,respectively,which were statistically significantly higher than those in non-severe group[(4.42±1.23)×10^(9)/L,(12.56±6.42)mg/L,(1.34±3.46)ng/ml,and(23.21±2.33)%,respectively](t=3.324,5.435,16.689,3.494,P<0.05).The levels of blood platelet,CD4^(+)T lymphocyte,CD4^(+)/CD8^(+)T lymphocyte ratio,and NK cell in severe group were(124.00±73.00)×10^(9)/L,(26.63±6.23)%,(0.96±0.23)%,and(10.23±4.11)%,respectively,which were statistically significantly lower than those in non-severe group[(302.00±96.00)×10^(9)/L,(33.43±5.62)%,(1.25±0.49)%,and(19.83±6.35)%,respectively](t=2.543,3.745,5.243,and 2.341,P<0.05).There were statistically significant differences in non-severe cases/severe cases ratio,the levels of CRP and PCT between the children of adenovirus type 3 and the children of adenovirus type 7(P<0.05).Conclusion For the children diagnosed as adenoviral pneumonia during early detection,high inflammation indexes or low immune function indicate severe adenoviral pneumonia,and it is necessary to be alert to the possibility of adenovirus type 7.
作者
张帆
李霄
李岚
何美娟
ZHANG Fan;LI Xiao;LI Lan(Jiangxi Provincial Children’s Hospital,Nanchang,Jiangxi 330000,China)
出处
《中国妇幼保健》
CAS
2021年第24期5686-5688,共3页
Maternal and Child Health Care of China
基金
江西省卫生计生委科技计划项目(20195566)。
