摘要
目的观察羟氯喹联合泼尼松治疗妊娠合并系统性红斑狼疮(SLE)的临床效果。方法选取2015年1月-2019年1月厦门大学附属中山医院收治的妊娠合并SLE患者68例,按照随机数字表法分为观察组和对照组,每组34例。对照组患者口服醋酸泼尼松片,观察组患者在对照组的基础上加服硫酸羟氯喹片。比较2组患者妊娠期间的SLE活动指数(SLEDAI)评分、不良反应、治疗前后血脂水平、妊娠结局、新生儿出生体质量、出生后5 min Apgar评分、新生儿窒息发生率。结果妊娠初期,2组患者SLEDAI评分比较差异无统计学意义(P>0.05);妊娠中期观察组患者SLEDAI评分低于妊娠初期及对照组(P<0.05);妊娠晚期2组患者SLEDAI评分均较妊娠初期降低,且观察组患者低于对照组(P<0.05)。治疗期间,观察组、对照组患者不良反应发生率分别为5.88%、14.71%,组间比较差异无统计学意义(χ^(2)=1.433,P=0.427)。治疗后,观察组患者TC及TG水平均显著低于治疗前及对照组(P<0.05),对照组患者治疗前后TC及TG水平比较差异无统计学意义(P>0.05)。观察组患者提前终止妊娠1例,对照组患者提前终止妊娠2例。观察组患者足月妊娠率显著高于对照组,早产率显著低于对照组,差异均有统计学意义(P<0.05),2组患者终止妊娠发生率比较差异无统计学意义(P>0.05)。观察组新生儿出生体质量、出生后5 min Apgar评分、新生儿窒息发生率与对照组比较差异均无统计学意义(P>0.05)。结论羟氯喹联合泼尼松治疗妊娠合并SLE更具有更好疗效,可有效稳定病情,改善血脂、妊娠结局及新生儿情况,安全可靠。
Objective To observe the clinical effect of hydroxychloroquine combined with prednisone in the treatment of pregnancy complicated with systemic lupus erythematosus(SLE).Methods A total of 68 pregnancy patients with SLE admitted to Zhongshan Hospital Affiliated to Xiamen University from January 2015 to January 2019 were selected and divided into observation group and control group according to random number table method,with 34 cases in each group.Control group was given prednisone acetate tablet,observation group was given hydroxychloroquine sulfate tablet on the basis of control group.The coefficient of SLE activity index(SLEDAI),adverse reactions,lipid level before and after treatment,pregnancy outcome,weight of newborn at birth,pressume 5 min Apgar table after birth,and incidence of neonatal asphyxia were compared between the two groups.Results In the first trimester,there was no significant difference in SLEDAI score between 2 groups(P>0.05);In the middle of a pregnancy,the SLEDAI score of observation group was lower than that of the first trimester and control group(P<0.05);In the third trimester,SLEDAI scores in both groups were lower than those in the first trimester,and the observation group was lower than the control group(P<0.05).During treatment,the incidence of adverse reactions was 5.88%in the observation group and 14.71%in the control group,and there was no significant difference between the two groups(χ^(2)=1.433,P=0.427).After treatment,the levels of TC and TG in observation group were significantly lower than before treatment and control group(P<0.05),while there were no significant difference in TC and TG levels in control group before and after treatment(P>0.05).1 case of early termination of pregnancy in the observation group and 2 cases of early termination of pregnancy in the control group.The term pregnancy rate in the observation group was significantly higher than that in the control group,and the preterm birth rate was significantly lower than that in the control group,the differences w
作者
林倩如
黄秀敏
LIN Qianru;HUANG Xiumin(Department of Obstetrics and Gynecology,Zhongshan Hospital Affiliated to Xiamen University,Fujian Province,Xiamen 361000,China)
出处
《临床合理用药杂志》
2021年第31期28-30,34,共4页
Chinese Journal of Clinical Rational Drug Use
关键词
妊娠
系统性红斑狼疮
羟氯喹
泼尼松
血脂
Pregnancy
Systemic lupus erythematosus
Hydroxychloroquine
Prednisone
Blood lipid
