摘要
目的探究贝利尤单抗治疗系统性红斑狼疮(SLE)的效果.方法选取2020年1月—2022年12月建湖县人民医院收治的60例SLE患者为研究对象,根据随机数字表法将其分为对照组和观察组,每组30例.对照组采用泼尼松联合硫酸羟氯喹治疗,观察组在此基础上采用贝利尤单抗治疗.对比两组患者的治疗效果.结果观察组的治疗总有效率为93.33%,高于对照组的70.00%,差异有统计学意义(P<0.05).观察组的不良反应发生率为10.00%,低于对照组的33.33%,差异有统计学意义(P<0.05).治疗后,观察组的红细胞沉降率、C反应蛋白、免疫球蛋白G、24 h尿蛋白定量、抗双链DNA抗体定量、抗核抗体定量、抗核小体抗体定量水平均低于对照组,补体3、补体4、血小板计数水平均高于对照组,组间差异有统计学意义(P<0.05).结论采用贝利尤单抗治疗SLE的效果理想,能够提高疗效,有效控制病情,且用药后不良反应较少,值得临床推广使用.
Objective To investigate the effect of beliuzumab in the treatment of systemic lupus erythematosus(SLE).Methods 60 SLE patients admitted to Jianhu County People's Hospital from January 2020 to December 2022 were selected as the research objects and were divided into a control group and an observation group according to random number table method,with 30 cases in each group.The control group was treated with prednisone combined with hydroxychloroquine sulfate,and the observation group was treated with beliuzumab on this basis.The therapeutic effects of the two groups were compared.Results The total effective rate of the observation group was 93.33%,higher than 70.00%of the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 10.00%,lower than 33.33%in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of erythrocyte sedimentation rate,C-reactive protein,immunoglobulin G,24 hours urinary protein,anti-double-stranded DNA antibody,anti-nuclear antibody and anti-nucleosome antibody in the observation group were lower than those in the control group,and the levels of complement 3,complement 4 and platelet count were higher than those in the control group,the differences between the groups were statistically significant(P<0.05).Conclusion The effect of beliuzumab in the treatment of SLE is ideal,which can improve the curative effect and effectively control the disease,and the adverse reactions after medication are less,which is worthy of clinical promotion.
作者
尤新新
YOU Xinxin(Department of Rheumatology and Immunology,Jianhu County People's Hospital,Yancheng Jiangsu,224700,China)
出处
《反射疗法与康复医学》
2024年第5期173-176,共4页
Reflexology And Rehabilitation Medicine
