摘要
目的探讨依诺肝素钠联合硫酸镁对早发型重度子痫前期患者胎盘生长因子(PIGF)、可溶性血管内皮生长因子受体1(sFlt-1)、血管性血友病因子(vWF)、p-选择素水平的影响。方法选取2017年1月至2020年1月本院收治的早发型重度子痫前期患者72例,采用随机数字表法分为观察组和对照组,各36例。对照组采用硫酸镁联合硝苯地平治疗,观察组采用依诺肝素钠联合硫酸镁治疗。比较两组PIGF、sFlt-1、vWF、p-选择素水平及妊娠结局。结果观察组PIGF水平高于对照组,sFlt-1、vWF、p-选择素水平低于对照组,差异有统计学意义(P<0.05);观察组胎儿窘迫、早产、剖宫产发生率均低于对照组,但差异无统计学意义。结论早发型重度子痫前期患者采用依诺肝素钠联合硫酸镁治疗,能有效改善PIGF、sFlt-1、vWF、p-选择素水平,改善妊娠结局。
Objective To investigate the effects of sodium enoxaparin and magnesium sulfate on placental growth factor(PIGF),soluble vascu-lar endothelial growth factor receptor 1(sFlt-1),vascular hemophilia factor(vWF),and p-selectin levels in patients with early onset serene prepre-eclampsia.Methods 72 patients with early-onset severe preeclampsia admitted to our hospital from January 2017 to January 2020 were divided into observation group and control group by random number table method,with 36 cases in each group.The control group was treated with magnesium sulfate combined with nifedipine,and the observation group was treated with enoxaparin sodium combined with magnesium sulfate.The PIGF,sFlt 1,vWF,p-selectin levels and pregnancy outcomes were compared between the two groups.Results The PIGF level in observation group was higher than that in control group,while the levels of sFlt-1,vWF and p-selectin were lower than those in control group,the difference was statistically significant(P<0.05).The incidence of fetal distress,premature delivery and cesarean section in the observation group was lower than that in the control group,but the difference was not statistically significant.Conclusion Enoxaparin sodium combined with magnesium sulfate can effectively improve PIGF,sFlt-1,vWF and P-selectin levels and improve pregnancy outcomes in patients with early-onset severe preeclampsia.
作者
徐学娟
刘艳
XU Xuejuan;LIU Yan(Department of Obstetrics,Tengzhou Central People's Hospital,Tengzhou City,Shandong Province,Tengzhou,Shandon,277500,China;Department of Obstetrics and Gynecology of Fugou Central Health Center,Tengzhou City,Shandong Province,Tengzhou,Shandong,277500,China)
出处
《当代医学》
2021年第30期85-87,共3页
Contemporary Medicine
