摘要
目的考察硫酸镁对子痫前期患者血清血管内皮生长因子(VEGF)、血管性血友病因子(vWF)的表达及尿蛋白定量(24h)的影响分析。方法将90例子痫前期患者随机数字表法分为观察组和对照组,每组45例。观察组患者给予硫酸镁5g静脉滴注,对照组患者给予安慰剂治疗。比较2组患者临床治疗效果,血压、尿蛋白定量(24h)水平以及血清VEGF、vWF表达水平。结果治疗前2组患者各指标差异无统计学意义(P>0.05)。治疗后观察组患者治疗有效率显著高于对照组(χ2=17.857,P<0.01)。治疗后观察组患者血压和尿蛋白定量(24h)水平显著低于对照组(t=2.663,t=76.656,P<0.01)。治疗后观察组患者血清VEGF显著高于对照组、vWF表达水平显著低于对照组(t=3.707,t=6.701,P<0.01)。结论硫酸镁通过影响子痫前期患者血清VEGF、vWF的表达水平改善患者临床症状。
Objective To investigate the effect of magnesium sulfate on the expression of 24 hours urinary protein and serum vascular endothelial growth factor （VEGF）, and von willebrand factor （vWF） in patients with preeclampsia. Methods Ninety cases of patients with preeclampsia were randomly divided into observation group and control group, 45 cases in each group. The observation group was treated with magnesium sulfate 5 g intravenously, and the control group was treated with placebo. To compare the clinical effect of the two groups, blood pressure, urine protein level of 24 hours and serum VEGF, vWF expression level were examined. Results Before treatment, there was no significant difference in the two groups （ P 〈0.05）. The effective rate of the observation group after treatment was significantly higher than that of the control group （ X2 = 17. 857,P 〈0. 01）. After treatment, blood pressure and urine protein level of 24 hours in the observation group were significantly lower than those in the control group （ t = 2. 663,t = 76. 656,P 〈0.01）. The expression level of VEGF was significantly higher than that in control group and vWF in the observation group was significantly lower than that in the control group （ t = 3. 707,t = 6. 701 ,P 〈0.01）. Conclusion The clinical symptoms of patients with preeclampsia were improved by the effect of magnesium sulfate on through influencing the level of serum VEGF and vWF.
出处
《山西医药杂志》
CAS
2016年第16期1862-1864,共3页
Shanxi Medical Journal
基金
深圳市宝安区科技计划(2015113)
关键词
子痫
硫酸镁
血管内皮生长因子类
因子Ⅷ
Preeclampsia
magnesium sulfate
Vascular endothelial growth factors
Factor
