摘要
目的探讨抗组胺药联合丹参注射液治疗过敏性紫癜疗效及对炎性因子影响。方法本次研究时间为2019年1月至2020年2月,研究对象为我院过敏性紫癜患者(n=84),根据不同的治疗方式分为单纯组(n=42,采用抗组胺药物治疗)与联合组(n=42,采用抗组胺药联合丹参注射液治疗),比较两组患者的临床治疗疗效与治疗前、治疗后的炎性因子水平以及各项临床症状消失时间。结果单纯组临床治疗总有效率为80.95%,联合组为95.24%,前者明显低于后者(P<0.05)。两组患者采用不同方式治疗前各项炎性因子水平比较,差异无统计学意义(P>0.05);治疗后,联合组IL-6、IL-18、IL-23以及TNF-a水平均明显低于单纯组(P<0.05)。联合组患者的紫癜消失时间、皮疹消失时间、腹痛消失时间、关节肿痛消失时间,均明显短于单纯组,具有统计学意义(P<0.05)。结论采用抗组胺药联合丹参注射液治疗过敏性紫癜患者,能获得良好的治疗疗效,不仅能减轻患者的病症,还能改善患者的炎性因子水平,值得应用。
Objective To investigate the effect of antihistamine combined with Danshen injection on HenochSchonlein purpura and its effect on inflammatory factors. Methods From January 2019 to February 2020, patients with Henoch Schonlein purpura(n=84) were divided into simple group(n=42, treated with antihistamines) and combined group(n=42, treated with antihistamines combined with Danshen injection) according to different treatment methods. The clinical efficacy and the levels of inflammatory factors before and after treatment were compared between the two groups as well as the disappearance time of clinical symptoms. Results A total effective rate of 80.95% in the simple group was significantly lower than 95.24% in the combined group(P<0.05). There was no significant difference in the levels of inflammatory factors before treatment between the two groups(P>0.05), and the levels of IL-6、IL-18、IL-23 and TNF-a in the combined group were significantly lower than those in the simple group(P<0.05).The disappearance time of purpura, rash, abdominal pain and joint swelling in the combined group were significantly shorter than those in the simple group(P<0.05). Conclusion The treatment of Henoch-Schonlein purpura with antihistamine combined with Danshen injection can obtain good therapeutic effect, not only alleviate the disease of patients, but also improve the level of inflammatory factors in patients, which is worthy of application.
作者
陈俊君
CHEN Jun-jun(Leizhou People's Hospital,Leizhou,Guangdong 524200)
出处
《智慧健康》
2021年第17期185-187,共3页
Smart Healthcare
关键词
抗组胺药
丹参注射液
过敏性紫癜
疗效
炎性因子
Antihistamine
Salvia miltiorrhiza injection
Henoch-Schonlein purpura
Effect
Inflammatory factor
