摘要
目的:探讨丹参酮治疗对过敏性紫癜患儿凝血功能、炎症因子及免疫功能的影响研究,指导临床用药。方法:选择本院已确诊的过敏性紫癜患儿130例,随机分为对照组和研究组各65例。对照组给予常规抗过敏药物治疗,研究组在对照组的基础上给予丹参酮治疗。比较两组治疗前后肾功能、炎症因子、凝血功能及免疫功能指标的变化。结果:两组治疗前肾功能、炎症因子、凝血功能及免疫功能各指标比较均无明显差异(P>0.05)。治疗后,两组肾功能Scr、BUN与Cysc水平,炎症因子PCT与CRP水平均显著降低(P<0.05)。研究组上述指标均明显低于对照组(P<0.05)。治疗后,两组APTT与PT水平均显著升高,FIB和ESR水平显著降低(P<0.05)。研究组APTT与PT水平均显著高于对照组,FIB和ESR水平明显低于对照组(P<0.05)。治疗后,两组IgG、C3与C4水平均显著降低(P<0.05)。研究组IgG、C3与C4水平均明显低于对照组(P<0.05)。结论:丹参酮联合抗过敏药物治疗过敏性紫癜患儿疗效显著,可明显减轻患儿肾功能损伤,缓解炎症应激反应,改善凝血功能,纠正免疫紊乱,值得临床推广应用。
Objective: To investigate the effects of tanshinone treatment on coagulation function, inflammatory factors and immune function in children with allergic purpura, and to guide clinical medication. Methods: 130 children with allergic purpura diagnosed in a certain hospital from November 2015 to June 1818 were selected. According to the random number table method, they were divided into control group and study group, 65 cases in each group.The control group was given conventional anti-allergic drugs, and the study group was treated with tanshinone on the basis of the control group.The changes of renal function, inflammatory factors, coagulation function and immune function were compared between the two groups before and after treatment. Results: There were no significant differences in renal function, inflammatory factors, coagulation function and immune function between the two groups ( P >0.05). After treatment, the levels of renal function Scr, BUN and Cysc and were significantly decreased in the two groups, and the inflammatory factors PCT, CRP levels were significantly decreased in the two groups ( P <0.05). The above indexes of the study group were significantly lower than the control group ( P <0.05). After treatment, APTT and PT levels were significantly increased in both groups, and FIB and ESR levels were significantly lower ( P <0.05). The levels of APTT and PT in the study group were significantly higher than those in the control group, and the FIB and ESR level was significantly lower than that in the control group ( P <0.05). After treatment, the levels of IgG, C3 and C4 were significantly lower in the two groups ( P <0.05). The levels of IgG, C3 and C4 in the study group were significantly lower than those in the control group ( P <0.05). Conclusion: Tanshinone combined with anti-allergic drugs has significant curative effects on children with Henoch-Schonlein purpura. It can significantly reduce renal function damage, alleviate inflammation stress response, improve coagulation function and correct i
作者
范忠祥
胡波
胡云海
米本勇
周永康
FAN Zhong-xiang;HU Bo;HU Yun-hai;MI Ben-yong;ZHOU Yong-kang(Department of paediatrics, Chengdu Fifth people's Hospital, Chengdu 611130, Sichuan, China)
出处
《海南医学院学报》
CAS
2019年第4期280-283,287,共5页
Journal of Hainan Medical University
基金
成都市卫生局科学研究基金(2012007)~~
关键词
丹参酮
过敏性紫癜患儿
凝血功能
炎症因子
免疫功能
Tanshinone
Children with allergic purpura
Coagulation
Inflammatory factors
Immune function
