摘要
目的:探讨泼尼松联合氨甲苯酸注射液对过敏性紫癜患者的疗效及对患者炎症因子和凝血功能的影响。方法:过敏性紫癜患者98例随机分为观察组49例与对照组49例。对照组采用泼尼松片治疗,观察组在对照组基础上加用氨甲苯酸注射液。两组疗程均为4周。比较两组治疗疗效,治疗前后血清炎症因子和凝血功能变化,腹痛消失时间、紫癜消失时间及关节疼痛消失时间及不良反应情况。结果:观察组治疗总有效率93.88%,高于对照组的73.47%(P<0.05)。治疗后,两组血清IL-12水平增加、IL-15和IL-23水平降低、D-D二聚体、Fib水平降低;且观察组血清IL-12水平高于对照组,IL-15、IL-23水平,以及D-D二聚体、Fib水平均低于对照组(P<0.05)。观察组腹痛消失时间、紫癜消失时间及关节疼痛消失时间均明显短于对照组(P<0.05)。两组药品不良反应发生率比较,差异无统计学意义(P>0.05)。结论:泼尼松联合氨甲苯酸注射液治疗过敏性紫癜患者疗效显著,可明显改善血清炎症因子水平和凝血功能,且安全性良好,优于单用泼尼松治疗。
Objective： To investigate the clinical efficacy of prednisone combined with aminomethylbenzoic acid in the treatment of patients with irritability purpura and its effects on inflammatory factors and coagulation function. Methods： Totally 98 cases of patients with irritability purpura were randomly divided into the observation group （ n = 49） and the control group （ n = 49）. The control group was treated with prednisone, while the observation group was given aminomethylbenzoic acid injection on the basis of the control group. Both groups were treated for 4 weeks. The efficacy of the two groups was compared, and the changes of serum inflammatory factors and coagulation function before and after the treatment, the disappearance time of stomachache, purpura and arthralgia and adverse drug reactions were also observed and compared. Results： The total effective rate of the observation group （93.88%） was significantly higher than that of the control group （73.47%, P 〈0.05）. After the treatment, the serum level of IL-12 increased, the IL-15 and IL-23 levels decrease, and the D-D dimer and Fib levels decreased in both groups ; the serum level of IL-12 in the observation group was higher than that in the control group, and the IL-15 and IL-23 levels were lower than those in the control group （P 〈0.05） ; the D-D dimer and Fib levels in the observation group after the treatment were lower than those in the control group （P 〈 0.05 ）. The disappearance time of abdominal pain, purpura and joint pain in the observation group was significantly shorter than that in the control group （P 〈 0.05 ）. ECG, blood and urine routine, liver and kidney function were normal in both groups without serious adverse reactions. Condusion： Prednisone combined with aminomethylbenzoic acid in the treatment of irritability purpura shows striking effects without obvious adverse reactions, and the actions may be related to reducing the inflammatory reaction and improving coagulation function, which is better t
出处
《中国药师》
CAS
2017年第5期845-847,共3页
China Pharmacist
关键词
泼尼松
氨甲苯酸注射液
疗效
炎症因子
凝血功能
Prednisone
Aminomethylbenzoic acid injecion
Efficacy
Inflammatory factors
Coagulation function
