摘要
目的探讨机械通气患者血清及支气管肺泡灌洗液中降钙素原(PCT)、载脂蛋白E(ApoE)、烟酰胺磷酸核糖转移酶(Nampt)水平对呼吸机相关性肺炎(VAP)的诊断作用。方法选取2015年12月—2016年12月行有创呼吸机辅助通气发生VAP患者23例为VAP组,以及同时期未发生VAP患者8例为非VAP组。分别于机械通气24、96和144 h取患者血清及支气管肺泡灌洗液标本,分别检测PCT、ApoE和Nampt水平。结果机械通气96和144 h,VAP组血清和灌洗液的PCT和ApoE水平高于非VAP组(P<0.01)。机械通气24、96和144 h,VAP组和非VAP组血清及灌洗液的Nampt水平比较差异均无统计学意义(P>0.05)。结论血清及支气管肺泡灌洗液PCT及ApoE水平测定,对VAP的早期诊断有着重要的指导意义。
Objective To investigate levels of procalcitonin (PCT), apolipoprotein E (ApoE) and nicotinamide phosphoribosyltransferase (Nampt) in serum and bronchoalveolar lavage fluid and their effects in diagnosis of ventilator-associated pneumonia (VAP). Methods A total of 23 patients with VAP, when they underwent invasive ventilator-assisted ventilation during December 2015 and December 2016, were selected as VAP group, and other 8 patients without VAP at the same period were selected as non-VAP group. Samples of serum and bronchoalveolar lavage fluid were collected at the 24 th , 96 th and 144 th h after mechanical ventilation, and then PCT, ApoE and Nampt levels were detected respectively. Results At the 96 th and 144 th h after mechanical ventilation, PCT and APOE levels in serum and lavage fluid in VAP group were significantly higher than those in non-VAP group ( P <0.01). There were no significant differences in Nampt levels in serum and lavage fluid at the 24 th , 96 th and 144 th h after mechanical ventilation between VAP and non-VAP groups ( P >0.05). Conclusion Determination of PCT and ApoE levels in serum and bronchoalveolar lavage fluid has important guiding significance in early diagnosis of VAP.
作者
李杨杨
韩丽娜
李莉
LI Yang-yang;HAN Li-na;LI Li(The First Department of Respiratory Diseases, the First Hospital of Handan, Handan, Hebei 056000, China)
出处
《解放军医药杂志》
CAS
2019年第3期88-90,共3页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
河北省医学科学研究重点课题(20171110)
