摘要
目的研究载脂蛋白E(ApoE)和MTHFR C677T基因多态性与精神分裂症患病及患者认知功能的关联。方法收集2018年1月1日至2020年1月1日海南省人民医院和海南省安宁医院诊治的精神分裂症患者84例及同期于海南省人民医院体检健康者84例为研究对象,检测ApoE和MTHFR C677T的基因型及认知功能,行相关性分析。结果ApoE基因型与精神分裂症无关(P>0.05);MTHFR C677T基因型与精神分裂症有关(P<0.05),对照组基因以CT(50%)为主,病例组基因以TT(36.47)及CT(45.23%)为主(P<0.05);认知功能的指标评分与精神分裂症有关(P<0.05);ApoE基因型与研究对象的认知功能无关,MTHFR C677T基因型与研究对象的认知功能相关(P<0.05)。结论ApoE基因多态性与患精神分裂症以及认知功能无相关性,MTHFR C677T基因多态性与患精神分裂症以及认知功能有相关性。
Objective To investigate the association of ApoE and MTHFR C677T gene polymorphisms with schizophrenia and cognitive function.Methods A total of 84 schizophrenic patients who were admitted to Hainan Provincial People′s Hospital and Anning Hospital from January 1,2018 to January 1,2020 and 84 healthy subjects who were admitted to Hainan Provincial People′s Hospital during the same period were collected.The genotypes and cognitive function of ApoE and MTHFR C677T were detected and the correlation analysis was performed.Results APOE genotype was not associated with schizophrenia(P>0.05).The MTHFR C677T genotype was associated with schizophrenia(P<0.05).The genotype was mainly CT(50%)in the control group,whereas was mainly TT(36.47)and CT(45.23%)in the study group(P<0.05).The index score of cognitive function was related to schizophrenia(P<0.05).APOE genotype was not associated with cognitive function,while MTHFR C677T genotype was associated with cognitive function(P<0.05).Conclusions APOE gene polymorphism is not associated with schizophrenia and cognitive function,while MTHFR C677T gene polymorphism is related with schizophrenia and cognitive function.
作者
李佳
林荫
吉训琦
康延海
董洁
LI Jia;LIN Yin;JI Xunqi;KANG Yanhai;DONG Jie(Department of Psychiatry,Hainan Provincial People′s Hospital,Haikou 570000,China;不详)
出处
《实用医学杂志》
CAS
北大核心
2021年第18期2391-2394,共4页
The Journal of Practical Medicine
基金
海南省卫生计生行业科研项目(编号:19A200061)。
