摘要
目的了解血管性抑郁患者血清中瞬时受体电位通道1（transient receptor potential channel1，TRPCI）的改变。方法选取血管性抑郁患者58名，原发性抑郁症患者49名，健康对照者38名。通过ELISA技术，检测受试者血清中TRPCI的水平。使用HAMD-17测评抑郁患者的严重程度。分析不同年龄阶段TRPCI的改变；分析不同致病原因（脑梗死、缺血性脑血管病、陈旧性脑出血、脑微量出血、血管危险因素等）所致血管性抑郁患者间TRPCI水平的差异；进一步分析TRPCI水平与抑郁症状严重程度之间的关系。结果（1）所有血管性抑郁患者的血清TRPCI水平[（643．76±118．43）pg／m1]低于健康对照组[（712．48±98．75）pg／ml]，60岁以上的血管性抑郁患者的TRPCI水平[（601．43±113．55）pg／ml]明显低于60岁以上原发性抑郁患者[（626．32±125．46）pg／ml]和60岁以上健康被试[（721．84±99．62）pg／ml]。（2）在导致血管性抑郁的各种原因当中，脑梗死、缺血性脑血管病、脑微量出血的患者TRPCI水平明显降低（P〈0．05），而陈旧性脑出血、血管危险因素的患者TRPCI改变不明显（P〉0．05）。（3）血管性抑郁组（r=-0．962，P〈0．05）和原发性抑郁组（r=-0．674，P〈0．05）的血清TRPCI水平与HAMD-17评分均呈负相关。结论TRPCI水平在血管性抑郁患者中较低，在脑梗死、缺血性脑血管病、脑微量出血所导致的血管性抑郁患者中改变更明显。TRPCI水平越低，抑郁程度越重。TRPCI对血管性抑郁患者的神经血管保护作用降低，可作为血管性抑郁研究的生物学标志。
Objective To understand the changes of serum transient receptor potential channel 1 （TRPC1） in patients with vascular depression. Methods 58 patients with vascular depression ,49 patients with major depressive disorder and 38 healthy controls were recruited.The TRPC1 of all subjects were detected by ELISA.Patients with vascular depression and patients with primary depression were scaled by HAMD- 17.The level of TRPC1 was contrasted in different ages groups and in different nosogenesis （cerebral infarction,isehemic eerebrovascular disease, old cerebral hemorrhage, cerebral microbleeds, vascular risk factors, etc.） of vascular depression.The relationship between TRPC1 level and severity of depressive symptoms was further analyzed. Results （l）The level of TRPC1 of serum（（643.76±118.43）pg/ml） was decreased in patients with vascular depression compared with that in healthy controls （ （712.48± 98.75 ） pg/ml）.The level of TRPC 1 in patients with vascular depression over 60 years （ （601.43 ± 113.55 ）pg/ml ）was lower than that in patients with major depressive disorder over 60 years （ （626.32± 125.46）pg/ml） and healthy controls over 60 years（ （ 721.84± 99.62） pg/ml） . （2） Among the various causes of vascular depression, the level of TRPC1 in patients with eerebral infarction, ischemic eerebrovaseular disease and eerebral microbleeds was significantly lower （P〈0.05）. （3） The levels of TRPC1 in the patients with vascular depression （r=-0.962, P〈0.05） and patients with major depressive disorder （r=-0.674,P〈0.05） were negatively correlated with HAMD-17 score. Conclusion The level of TRPC1 is lower in patients with vaseular depression,which is more obvious in patients with cerebral infarction,ischemic cerebrovascular disease, and cerebral microhaemorrhage.The lower the level of TRPC 1, the more severe the depression.The neuroprotective effect of TRPC 1 is reduced in patients with vascular depression.The TRPC1 can be used as a biomarker for vascu
作者
钟静玫
武绍远
陈辉
朱艳青
杨文
李丹丹
姬从花
刘晓娟
Zhong Jingmei;Wu Shaoyuan;Chen Hui;Zhu Yanqing;Yang Wen;Li Dandan;Ji Conghua;Liu Xiaojuan(Department of Clinical Psychology,the First People＇ s Hospital of Yunnan Province,Kunming 650032,Chin)
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2018年第7期623-627,共5页
Chinese Journal of Behavioral Medicine and Brain Science
基金
云南省应用基础研究基金（昆医联合专项）资助项目[2017FE468（-129）]
关键词
血管性抑郁
抑郁症
瞬时受体电位通道1
Vascular depression
Major depressive disorder
Transient receptor potential channel 1
