摘要
目的分析评估给予门诊老年原发高血压合并糖尿病患者缬沙坦、氨氯地平联合治疗对于不良反应产生的影响。方法选择该院门诊2019年4月—2020年1月收治的老年原发高血压合并糖尿病患者110例作为研究主体,选择应用方便抽样法将纳选对象均匀划分为对照组和观察组,对照组在治疗期间应用缬沙坦单药治疗,观察组则联合应用缬沙坦、氨氯地平,对比评估临床治疗效果,涉及指标包含血压水平、血糖指标、血压控制达标率、不良反应发生率、临床治疗有效率。结果治疗前,两组血糖指标比较,差异无统计学意义(P>0.05);治疗后,和对照组进行比较,观察组血糖指标降低幅度较大,差异有统计学意义(P<0.05);治疗前,对照组、观察组舒张压、收缩压指标数值比较,差异无统计学意义(P>0.05);治疗后,与对照组相比,观察组血压水平控制效果较好,差异有统计学意义(P<0.05);对照组血压指标控制达标率为61.82%,观察组为87.27%,组间差异有统计学意义(χ^(2)=9.390,P<0.05);两组用药后不良反应发生概率比较,差异无统计学意义(P>0.05);对照组临床治疗有效率为85.45%,观察组所得数值为96.36%,组间对比差异有统计学意义(P<0.05)。结论将缬沙坦、氨氯地平联合应用于门诊老年原发高血压合并糖尿病治疗期间取得的效果理想,对于控制患者血糖以及血压指标具有积极意义,可促使患者将血压水平控制于正常范畴内,具有较高的用药安全性以及有效率,值得借鉴和推广。
Objective To analyze and evaluate the effect of combined treatment of valsartan and amlodipine on adverse reactions in elderly patients with primary hypertension and diabetes in outpatient clinics.Methods 110 elderly patients with primary hypertension and diabetes who were admitted to the outpatient clinic of the hospital from April 2019 to January 2020 were selected as the research subjects.The selected subjects were divided evenly into the control group and the observation group by the convenience sampling method.The control group was treated with valsartan as a single agent during the treatment period,and the observation group was treated with valsartan and amlodipine to compare and evaluate the clinical treatment effect,the indicators included blood pressure level,blood glucose indicators,blood pressure control compliance rate,incidence of adverse reactions,effective clinical treatment.Results Before treatment,there was no statistically significant difference between the two groups of blood glucose indicators(P>0.05);after treatment,compared with the control group,the observation group had a greater reduction in blood glucose indicators,and the difference was statistically significant(P<0.05).Before the comparison of the diastolic and systolic blood pressure index values between the control group and the observation group,the difference was not statistically significant(P>0.05);after treatment,compared with the control group,the observation group had better blood pressure control effect,and the difference was statistically significant(P<0.05);the control group's blood pressure index control compliance rate was 61.82%,and the observation group was 87.27%,the difference between the groups was statistically significant(χ^(2)=9.390,P<0.05);the difference in the probability of adverse reactions between the two groups was not statistically significant significance(P>0.05);the effective rate of clinical treatment in the control group was 85.45%,and the value obtained in the observation group was 96.36%.The differen
作者
刘莉莉
LIU Lili(Department of General Medicine,the Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian Province,350004China)
出处
《糖尿病新世界》
2021年第11期47-50,共4页
Diabetes New World Magazine
关键词
门诊
老年原发高血压
糖尿病
缬沙坦
氨氯地平
不良反应
Outpatient
Elderly essential hypertension
Diabetes
Valsartan
Amlodipine
Adverse reactions
