摘要
目的探讨高血压(HT)共患焦虑抑郁患者的证型分布特点,分析ET-1、hs-CRP、PP的证型分布规律。方法收集332例患者中有227例符合纳入标准,其中肝火亢盛型58例、阴虚阳亢型61例、痰湿壅盛型57例、肝郁脾虚型51例,采用焦虑自评量表(SAS)、抑郁自评量表(SDS)分别予以评分,评估焦虑、抑郁状况,对其结果进行统计分析。结果肝火亢盛型、阴虚阳亢型、肝郁脾虚型与焦虑状态呈负相关,痰湿壅盛型与抑郁状态呈负相关。SAS评分关联证型排序为肝火亢盛型>阴虚阳亢型>肝郁脾虚型>痰湿壅盛型;SDS评分关联证型排序为痰湿壅盛型>肝郁脾虚型>肝火亢盛型>阴虚阳亢型。肝火亢盛型、痰湿壅盛型的ET-1水平明显增高,P<0.05;阴虚阳亢型、痰湿壅盛型的hs-CRP水平增高,P<0.05;阴虚阳亢型的PP水平显著增大,P<0.05。结论HT共患焦虑抑郁患者各证型具有各自的临床分布特征,ET-1、hs-CRP、PP水平呈现出相应的证型分布趋归性。
Objective To explore the characteristics of syndrome type distribution of hypertension(HT)patients with anxiety and depression,and to analyze the rule of syndrome type distribution of ET-1,hs-CRP,and PP.Methods A total of 332 patients were collected,of which 227 cases met the inclusion criteria,including 58 cases of Ganhuokangsheng type(GHKS),61 cases of Yinxuyangkang type(YXYK),57 cases of Tanshiyongsheng type(TSYS),and 51 cases of Ganyupixu type(GYPX).The SAS and SDS were used to score them,evaluate their anxiety and depression,and statistically analyze their results.Results GHKS,YXYK and GYPX were negatively correlated with anxiety,and TSYS was negatively correlated with depression.The SAS scores were ranked as GHKS>YXYK>GYPX>TSYS;the SDS scores were ranked as TSYS>GYPX>GHKS>YXYK.The ET-1 level was significantly higher in the GHKS and TSYS,P<0.05;the hs-CRP level was higher in the YXYK and TSYS,P<0.05;the PP level was significantly higher in the YXYK,P<0.05.Conclusion Each syndrome type of HT patients with anxiety and depression has its own clinical distribution characteristics,and the levels of ET-1,hs-CRP,and PP show a corresponding trend of syndrome type distribution.
作者
刘镇
古春花
肖纯
李建松
彭智勇
牛效清
周蔚华
黄宝怡
LIU Zhen;GU Chunhua;XIAO Chun;LI Jiansong;PENG Zhiyong;NIU Xiaoqing;ZHOU Weihua;HUANG Baoyi(Traditional Chinese Medicine Hospital of Bao'an District,Shenzhen City,Shenzhen 518133,China;People's Hospital of Bao'an District,Shenzhen City,Shenzhen 518133,China)
出处
《中国医药指南》
2023年第15期1-4,共4页
Guide of China Medicine
基金
2021年深圳市宝安区科技创新局基础研究(医疗卫生类)项目,项目编号:2021JD159。
关键词
高血压
焦虑抑郁
中医证型
内皮素-1
高敏C反应蛋白
脉压差
Hypertension
Anxiety and depression
TCM syndrome types
Endothelin-1
High-sensitivity C-reactive protein
Pulse pressure difference
