摘要
紫檀芪是一种白藜芦醇的天然二甲基类似物,具有多种药理活性,且与白藜芦醇相比具有更高的生物利用度。紫檀芪具有抗氧化、抗炎、免疫调节等作用,多项体内和体外实验表明紫檀芪有一定的抗纤维化作用,有可能成为肝、肾、肺、心肌纤维化的治疗药物。紫檀芪抗纤维化机制涉及肿瘤转化因子-β1、Smads蛋白、Sirt1和miR-15等,其治疗纤维化疾病的可行性和具体机制值得进一步探究。
Pterostilbene is a natural dimethyl analog of resveratrol, which has a variety of pharmacological activities and has higher bioavailability than resveratrol. Pterostilbene has anti-oxidation, anti-inflammatory, immune regulation and other effects. A number of in vivo and in vitro experiments show that pterostilbene has a certain anti-fibrosis effect, and may become a therapeutic drug for liver, kidney, lung, and myocardial fibrosis. The anti-fibrosis mechanism of pterostilbene involves tumor transforming factor-β1, Smads protein, Sirt1 and miR-15, etc. The feasibility and specific mechanism of pterostilbene in treating fibrotic diseases deserve further investigation.
作者
王若利
岳红梅
王潇
冯涛
刘睿超
WANG Ruo-li;YUE Hong-mei;WANG Xiao;FENG Tao;LIU Rui-chao(The First Clinical Medical College of Lanzhou University,Lanzhou GANSU 730000,China;Department of Respiratory and Critical Care Medicine,the First Hospital of Lanzhou University,Lanzhou GANSU 730000,China)
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2021年第7期494-498,共5页
Chinese Journal of New Drugs and Clinical Remedies
基金
甘肃省社会发展类重点研发计划项目(18YF1FA106)。
关键词
纤维化
疾病
紫檀碱类
紫檀芪
fibrosis
disease
pterocarpans
pterostilbene
