摘要
热休克蛋白90(Hsp90)是Hsp家族中的一员,广泛存在于雄性动物的性腺中。Hsp90在雄性生殖中发挥重要作用,在人与动物的性腺中会导致生殖过程不同环节的变化。Hsp90可以调控生精细胞的分裂,参与精子发生过程,在生殖细胞的快速定位、精子微管的形成、保护精子免受氧化应激、诱导顶体反应等过程中发挥不可缺少的作用;同时研究发现Hsp90在少、弱精子症患者精子中的定位和表达有明显的的变化。本文就Hsp90在雄性生殖及男性不育患者精子中相关研究进行分析,进而对男性不育的治疗提供新的研究方向。
Heat shock protein 90(Hsp90),as a member of the Hsp family and widely found in the gonads of humans and animals,plays an essential role in male reproduction and induces various changes in the process of reproduction.Hsp90 regulates the division of germ cells and participates in spermatogenesis,location of germ cells,formation of sperm microtubes,protection of sperm from oxidative stress,and inducement of acrosomal reaction.Studies showed significant changes in location and expression of Hsp90 in the sperm of oligospermia and asthenospermia patients.This paper presents an overview of Hsp90 in male reproduction and male infertility and a prospect of the treatment of male infertility.
作者
周乐乐
黄建豪(综述)
陈云
张守全(审校)
ZHOU Le-le;HUANG Jian-hao;CHEN Yun;ZHANG Shou-quan(Laboratory of Animal Breeding,South China Agricultural University,Guangzhou,Guangdong 510642,China)
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2021年第4期351-355,共5页
National Journal of Andrology
基金
国家自然科学基金面上项目(31572397)。
关键词
热休克蛋白90
精子
雄性生殖
男性不育
heat shock protein 90
sperm
male reproduction
male infertility
