摘要
细胞焦亡是一类与炎症反应密切相关、由Gasdermin蛋白介导、依赖于caspase活性的程序性细胞死亡方式,其典型特征是细胞膜肿胀破裂,促炎性因子和细胞内容物释放到细胞外环境,引起机体产生炎症反应。在炎症反应期间,NLRP3、caspase、Gasdermin D(GSDMD)、IL-1β等细胞焦亡相关因子在心血管疾病的发生和发展中发挥重要作用。本文着重介绍了细胞焦亡的主要发生机制,深入分析了细胞焦亡在动脉粥样硬化、冠心病、心肌梗死、糖尿病心肌病、压力超负荷所致的心室重构和心脏肥大、心肌炎、心律失常等心血管疾病中的作用,并总结了靶向细胞焦亡治疗心血管疾病的潜在治疗方法,为临床心血管疾病的防治研究提供基础。
Pyroptosis is a form of programmed cell death which is closely related to the inflammatory response,mediated by Gasdermin protein and depends on the activity of cysteine aspartate specific protease(caspase).Pyroptosis is typically characterized by swelling and rupture of cell membrane,release of proinflammatory factors and cell contents from the plasma membrane to the extracellular environment,which aggravates inflammatory response.During the inflammatory response,NLRP3,caspase,Gasdermin D(GSDMD)and IL-1βplay important roles in the occurrence and development of cardiovascular diseases.In this review,we focus on the role of pyroptosis in cardiovascular diseases including atherosclerosis,coronary heart disease,myocardial infarction,diabetic cardiomyopathy,pressure overload-induced ventricular remodeling and cardiac hypertrophy,myocarditis,arrhythmia and so on,and summarize the potential treatment targeting pyroptosis.It will provide the basis for prevention and treatment of clinical cardiovascular diseases.
作者
王佳慧
梁欢
于影
高琴
WANG Jia-Hui;LIANG Huan;YU Ying;GAO Qin(Department of Physiology,Bengbu Medical College,Bengbu 233000,China;Key Laboratory of Basic and Clinical Cardiovascular Diseases,Bengbu Medical College,Bengbu 233000,China)
出处
《生理学报》
CAS
CSCD
北大核心
2021年第2期329-341,共13页
Acta Physiologica Sinica
基金
supported by grants from the National Natural Science Foundation of China(No.81770297)
the Scientific Research and Innovation Team of Bengbu Medical College,China(No.Byycx1901)。
