摘要
多细胞生物的细胞凋亡(apoptosis)和炎症反应(inflammation)分别在内稳态维持和对抗外源微生物入侵的过程中具有重要作用.凋亡小体和炎症小体则是调节这两种生物学过程的关键复合物.凋亡小体和炎症小体的功能都是作为caspase的激活平台,但是前者激活caspase-9,而后者则是激活炎症性caspase-1.本文综述近年来关于这两类复合体激活机制的研究进展.
In multicellular organisms, the ligand-induced multiprotein complexes apoptosomes and inflammasomes are major players mediating apoptosis and inflammation, respectively. Both types of complexes function as a caspase-activating platform, but apoptosomes are specific for the apoptotic caspases such as caspase-9, whereas inflammasomes for inflammatory caspases like caspase-1. Here we summarize recent progresses on the molecular mechanisms underlying assembly and activation of the two types of protein complexes.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2014年第10期1056-1062,共7页
Progress In Biochemistry and Biophysics
