摘要
【目的】探讨五音疗法联合耳穴压豆对胃癌根治术后行腹腔热灌注化疗患者焦虑和疼痛的治疗效果及其可能的作用机制。【方法】将120例胃癌术后行腹腔热灌注化疗患者随机分为五音疗法组、耳穴压豆组、联合治疗组和对照组,每组各30例。对照组给予腹腔热灌注化疗常规护理,五音疗法组、耳穴压豆组、联合治疗组在常规护理基础上分别给予五音疗法、耳穴压豆、五音疗法联合耳穴压豆的中医护理措施。应用焦虑自评量表(SAS)评分、匹兹堡睡眠质量指数(PSQI)评分、汉密尔顿抑郁量表(HAMD)评分和疼痛数字量表(NRS)评分评估4组患者干预前后焦虑状态、睡眠质量、抑郁情况和疼痛程度的变化情况,并观察4组患者外周血CD4^(+)/CD8^(+)T细胞、热休克蛋白90a(HSP90a)和C反应蛋白(CRP)的变化情况。【结果】(1)干预后,4组患者的SAS评分、PSQI评分和疼痛NRS评分均较干预前降低(P<0.05);组间比较,联合治疗组的降低作用均优于其他3组,五音疗法组和耳穴压豆组的降低作用均优于对照组,差异均有统计学意义(P<0.05或P<0.01)。(2)干预后1周,五音疗法组、耳穴压豆组、联合治疗组和对照组抑郁状态疗效的总有效率分别为50.0%(15/30)、76.7%(23/30)、90.0%(27/30)和30.0%(9/30);组间比较,联合治疗组的抑郁状态疗效优于其他3组,五音疗法组和耳穴压豆组的抑郁状态疗效优于对照组,差异均有统计学意义(P<0.05或P<0.01)。(3)干预后,联合治疗组患者的外周血CD4^(+)/CD8^(+)T细胞比值较其他3组显著提高,应激反应指标HSP90a和CRP水平较其他3组显著下降,差异均有统计学意义(P<0.05或P<0.01);而五音疗法组和耳穴压豆组的外周血CD4^(+)/CD8^(+)T细胞比值较对照组显著提高,应激反应指标HSP90a和CRP水平较对照组显著下降,差异均有统计学意义(P<0.05)。【结论】五音疗法联合耳穴压豆能有效缓解胃癌患者行腹腔热灌注化�
Objective To explore the therapeutic effect of five-note therapy combined with auricular point seedpressing therapy on relieving anxiety and pain in gastric cancer patients undergoing postoperative intraperitoneal hyperthermic perfusion chemotherapy and to explore its underlying mechanism.Methods A total of 120 gastric cancer patients treated by postoperative intraperitoneal hyperthermic perfusion chemotherapy were randomly divided into five-note therapy group,auricular point seed-pressing therapy group,combination group and control group.Each group had 30 cases.The control group was given conventional nursing for intraperitoneal hyperthermic perfusion chemotherapy.The five-note therapy group,auricular point seed-pressing therapy and combination group were given traditional Chinese medicine nursing respectively with five-note therapy,auricular point seedpressing therapy and the combination of five-note therapy and auricular point seed-pressing therapy.We applied Self-rating Anxiety Scale(SAS)scores,Pittsburgh Sleep Quality Index(PSQI)scores,Hamilton Depression Rating Scale(HAMD)scores and numerical rating scale(NRS)scores to evaluate the degree of anxiety,sleeping quality,depression and pain degree in the four groups,and assessed the changes of peripheral levels of CD4^(+)/CD8^(+)T cells,heat shock protein 90a(HSP90a)and C-reactive protein(CRP)by testing blood biochemical indicators in the four groups as well.Results(1)After intervention,SAS scores,PSQI scores and pain NRS scores in the 4 groups were obviously decreased in comparison with those before intervention(P<0.05),and the decrease in the combination group was superior to that in the other 3 groups,the effect on decreasing SAS scores,PSQI scores and pain NRS scores in the five-note therapy group and auricular point seed-pressing therapy was superior to that in the control group,the difference being statistically significant(P<0.05 or P<0.01).(2)After intervention for one week,the total effective rate for depression in the five-note therapy group,auricular
作者
符梅华
王鑫
陈燕云
陈惠
姚任
FU Mei-Hua;WANG Xin;CHEN Yan-Yun;CHEN Hui;YAO Ren(The Second Surgery Dept,of the First Affiliated Hospital,Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2021年第5期880-885,共6页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广东省中医药局科研项目(编号:20182035)。
关键词
胃癌术后
腹腔热灌注化疗
焦虑
疼痛
五音疗法
耳穴压豆
gastric cancer after surgery
intraperitoneal hyperthermic perfusion chemotherapy
anxiety
pain
five-note therapy
auricular point seed-pressing therapy
