摘要
目的探究妊娠期先兆性流产与生殖道感染的相关性及患者血清孕酮(PRG)、β-人绒毛膜促性腺激素(β-HCG)、糖链蛋白125(CA125)水平变化。方法选取2016年10月-2019年5月在海口市妇幼保健院妇产科就诊的妊娠期先兆性流产妇女118例为研究对象,根据妊娠结局不同分为良好组(n=41)和不良组(n=77),并以同期孕周相近的正常孕妇100名为对照组。三组均行生殖道病原体和血清PRG、β-HCG、CA125水平检测,比较三组生殖道感染阳性率及血清PRG、β-HCG、CA125水平,分析血清PRG、β-HCG、CA125水平对先兆性流产结局预测的准确性。结果不良组和良好组解脲支原体(36.36%、17.07%)、沙眼衣原体(36.36%、26.83%)、巨细胞病毒(42.86%、19.51%)、假丝酵母(33.77%、31.71%)感染阳性率高于对照组(2.00%、3.00%、5.00%、15.00%),且不良组感染阳性率高于良好组(P<0.05);良好组、不良组血清PRG、β-HCG水平低于对照组,且不良组低于良好组,良好组、不良组血清CA125水平高于对照组,且不良组高于良好组(P<0.05);血清PRG、β-HCG、CA125联合诊断敏感性为92.21%,高于血清CA125(79.22%)、β-HCG(77.92%)、PRG(72.73%)单独诊断。结论先兆性流产患者生殖道感染率、血清CA125水平高于正常孕妇,血清PRG、β-HCG水平低于正常孕妇,通过检测血清PRG、β-HCG、CA125水平,可预测评估先兆性流产结局。
OBJECTIVE To explore the correlation between threatened abortion and reproductive tract infection during pregnancy and reproductive tract infections and the changes of progesterone(PRG), β-human chorionic gonadotrophin(β-HCG) and carbohydrate antigen 125(CA125) levels. METHODS A total of 118 pregnant women with threatened abortion in obstetrics and gynecology department of Haikou Maternal and Child Health Hospital from Oct. 2016 to May 2019 were enrolled in the study. According to pregnancy outcomes, they were divided into the good prognosis group(n=59) and poor prognosis group(n=59), and 100 normal pregnant women with similar gestational weeks were recruited as the control group. Reproductive tract pathogens and the levels of serum PRG, β-HCG and CA125 were tested in all the three groups;the positive rate of reproductive tract infections and the levels of PRG, β-HCG and CA125 were compared among the three groups;the accuracy of serum PRG, β-HCG and CA125 levels in predicting the outcome of threatened abortion was analyzed. RESULTS The positive rates of Mycoplasma ureide(36.36%, 17.07%), Chlamydia trachomatis(36.36%, 26.83%), cytomegalovirus(42.86%, 19.51%) and Candida(33.77%, 31.71%) in the poor prognosis group and the good group were significantly higher than those in the control group, and the positive rates in of poor prognosis group was significantly higher than the good prognosis group(P<0.05). The levels of serum PRG and β-HCG in the good prognosis group and the poor prognosis group were significantly lower than those in the control group, and the poor prognosis group was significantly lower than those in the good group(P<0.05). The combined diagnostic sensitivity of serum PRG, β-HCG and CA125 was 92.21%, which was significantly higher than that of serum CA125(79.22%), β-HCG(77.92%) and PRG(72.73%) alone. CONCLUSION The reproductive tract infections rate and the level of serum CA125 in the patients with threatened abortion were higher than those in the normal pregnant women, and the levels of serum
作者
黄玲
陈燕娥
王颜
王小莉
吴帮鉴
HUANG Ling;CHEN Yan-e;WANG Yan;WANG Xiao-li;WU Bang-jian(Haikou Maternal and Child Health Hospital,Haikou,Hainan 570203,China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2021年第8期1244-1248,共5页
Chinese Journal of Nosocomiology
基金
海南省自然科学基金资助项目(20158312)。
关键词
先兆性流产
生殖道感染
糖类抗原125
Β-人绒毛膜促性腺激素
孕酮
Threatened abortion
Reproductive tract infections
Carbohydrate antigen 125
β-human chorionic gonadotrophin
Progesterone
