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基于“药物-成分-靶点”探讨中药复方辨证论治阴道炎的科学内涵 被引量:3

Exploring scientific connotation of traditional Chinese medicine compound on syndrome differentiation treatment for vaginitis based on“drug-component-target”
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摘要 阴道炎是目前常见的妇科疾病之一,具有发病率、复发率相对较高的特点。中药复方治疗阴道炎疗效突出、复发率较低,然而其治疗阴道炎的机制复杂,成分、靶点间关系尚不清楚。通过从中、西医角度对阴道炎病因、病机、治则进行对比,对中药复方辨证论治阴道炎的研究进展进行综述,并通过网络药理学对清热利湿、健脾利湿、滋阴补肾型中药复方治疗阴道炎的成分、靶点进行收集,说明中医辨证论治的治疗特点,解释了中医分证型治疗阴道炎的合理性,为中药复方治疗阴道炎的潜在药物发现及临床精准治疗提供参考。 Vaginitis is one of the common gynaecological diseases at present,which is characterized by a relatively high incidence rate and recurrence rate.Traditional Chinese medicine(TCM)compound has an outstanding curative effect on vaginitis and a low recurrence rate,the mechanism of treating vaginitis is complex,and the relationship between components and target is still unclear.By comparing the etiology,pathogenesis and treatment of vaginitis from the perspectives of TCM and Western medicine,we review the progress of research on the evidence-based treatment of vaginitis with TCM compound,and collect the components and targets of TCM compound for the treatment of vaginitis by clearing heat and draining dampness,invigorating spleen and removing dampness,and nourishing yin and reinforcing kidney through network pharmacology to illustrate the therapeutic characteristics of TCM syndrome differentiation treatment,explain the rationality of TCM to treat vaginitis by syndrome differentiation,and provide a reference for potential drug discovery and clinical precision treatment of vaginitis with TCM compound.
作者 李宗霖 谭晓华 王格瑩 陈春宇 马元甲 阿迪力·艾斯托拉 刘昌孝 杨继 何新 LI Zong-lin;TAN Xiao-hua;WANG Ge-ying;CHEN Chun-yu;MA Yuan-jia;ADIL Astulla;LIU Chang-xiao;YANG Ji;HE Xin(Guangdong Pharmaceutical University,Guangzhou 510006,China;Hetian Region Institute of Materia Medica,Hetian 848000,China;Tianjin Institude of Pharmaceutical Research,Tianjin 300462,China)
出处 《中草药》 CAS CSCD 北大核心 2023年第21期7232-7247,共16页 Chinese Traditional and Herbal Drugs
基金 国家自然科学基金资助项目(82174209) 和田地区本级技术研究与开发经费计划项目(202105)。
关键词 中药复方 阴道炎 阴道稳态 网络药理学 清热利湿 健脾利湿 滋阴补肾 traditional Chinese medicine compound vaginitis vaginal homeostasis network pharmacology clearing heat and draining dampness invigorating spleen and removing dampness nourishing yin and reinforcing kidney
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