摘要
目的:探讨妊娠早期流产的阴道超声影像表现及与血清瘦素、融合素-α(ADAM12)、糖类抗原-125(CA-125)的相关性。方法:选取2017年7月-2020年9月于我院就诊的419例具有早期先兆流产征象的孕妇患者,按妊娠结局分为妊娠早期流产组(流产组,61例)和正常早期妊娠组(正常组,358例)。所有患者均进行阴道超声检查,观察卵黄囊的大小和形态。测定胎儿冠臀长(CRL)、胎囊直径(GSD)、卵黄囊直径(YSD)和胎心率(FHR)。同时检测患者血清瘦素、ADAM12、CA-125水平。采用Spearman秩相关分析评价阴道超声影像学表现与血清瘦素、ADAM12、CA-125水平的相关性。结果:正常组孕妇超声影像表现可见孕囊形态饱满,孕周和胎芽大小相符,可清晰显示原始心管、卵黄囊和胎心波动。流产组孕妇部分超声影像表现可见卵黄囊过大、过小或未见显示,胎芽略小,卵囊位置位于宫腔中下段,孕囊外形稍欠规则,同时可见原始心管或胎心波动。流产组孕妇平均CRL、GSD、FHR均显著低于正常组,差异均有统计学意义(P<0.05);流产组患者平均YSD稍低于正常组,差异有统计学意义(P<0.05)。流产组孕妇各孕周CRL、GSD、FHR均显著低于正常组,差异均有统计学意义(P<0.05);流产组患者第6-7周YSD高于正常组、第8-9周和第10-11周YSD低于正常组,差异均有统计学意义(P<0.05)。流产组患者血清瘦素、ADAM12水平明显低于正常妊娠组,差异有统计学意义(P<0.05),流产组患者血清CA-125水平明显高于正常妊娠组,差异有统计学意义(P<0.05)。妊娠早期流产患者阴道超声参数CRL、GSD、FHR与血清瘦素、ADAM12呈正相关(P<0.05),与CA-125水平呈负相关(P<0.05)。结论:妊娠早期阴道超声及血清瘦素、ADAM12、CA-125可作为早期流产的有效预测因素,阴道超声参数CRL、GSD、FHR与血清瘦素、ADAM12、CA-125水平具有相关性,临床可通过测定这些指标以提高妊娠早期流产预测的准确�
Objective:To investigate the transvaginal ultrasound Findings of early pregnancy abortion and its relationship with serum leptin and fusin-α(ADAM12)and carbohydrate antigen-125(CA-125).Methods:419 pregnant women with signs of Early Threatened Abortion Treated in our hospital from July 2017 to September 2020 were divided into early pregnancy abortion group(abortion group,61 cases)and normal early pregnancy group(normal group,358 cases).All patients underwent transvaginal ultrasonography to observe the size and shape of yolk sac.Fetal crown-rump length(CRL),gestational sac diameter(GSD),yolk sac diameter(YSD)and fetal heart rate(FHR)were measured.At the same time,the levels of serum leptin,ADAM12 and CA-125 were detected.Spearman rank correlation analysis was used to evaluate the correlation between transvaginal ultrasound findings and serum leptin,ADAM12 and CA-125 levels.Results:Ultrasound images of normal pregnant women showed that the shape of gestational sac was full,the gestational weeks were consistent with the size of fetal bud,and the fluctuations of original heart tube,yolk sac and fetal heart could be clearly displayed.Some ultrasonic images of pregnant women in the abortion group showed that the yolk sac was too large,too small or not shown,the fetal bud was slightly small,the egg sac was located in the middle and lower segment of the uterine cavity,the shape of the gestational sac was slightly irregular,and the fluctuation of the original heart tube or fetal heart could be seen at the same time.The mean CRL,GSD and FHR of pregnant women in abortion group were significantly lower than those in normal group(P<0.05).The mean YSD of abortion group was slightly lower than that of normal group(P<0.05).CRL,GSD and FHR of pregnant women in abortion group in each gestational week were significantly lower than those in normal group(P<0.05);YSD in the abortion group was higher than that in the normal group at 6-7 weeks,and lower than that in the normal group at 8-9 weeks and 10-11 weeks(P<0.05).The levels of ser
作者
邓海霞
戴婷
吴园
肖炯
符声玉
莫利花
DENG Hai-xia;DAI Ting;WU Yuan;XIAO Jiong;FU Sheng-yu;MO Li-hua(Department of Ultrasonic diagnosis,Changsha Third Hospital,Changsha,Hunan,410007,China;Department of Ultrasonography,Hunan Maternal and Child Health Hospital,Changsha,Hunan,410008,China;Department of Obstetrics and Gynecology,Changsha Third Hospital,Changsha,Hunan,410007,China)
出处
《现代生物医学进展》
CAS
2022年第6期1160-1164,共5页
Progress in Modern Biomedicine
基金
湖南省卫生健康委科研项目(20161328)。
