摘要
目的:观察不同早期不良妊娠孕妇血清孕酮(P)、绒毛促性腺激素(HCG)和胎盘生乳素(HPL)变化,评价此3项指标对早期不良妊娠结局的预测价值。方法:2015年10月—2017年10月本院就诊的早期不良妊娠患者240例及同期正常妊娠孕妇100例(正常妊娠组)为研究对象,根据早期不良妊娠类型分为先兆流产继续妊娠者90例(先兆流产组),早期妊娠终止90例(妊娠终止组),异位妊娠60例(异位妊娠组),所有研究对象均于孕6、7、8周进行血清P、HCG和HPL检测,分析各组不同孕周3项指标的变化。结果:血清P、HCG和HPL水平在正常妊娠组、先兆流产组、异位妊娠组和妊娠终止组均依次降低(P<0.05);不同孕周时,P水平在各组间未见差异(P>0.05),而血清HCG和HPL水平在正常妊娠组和先兆流产组呈上升(P<0.05)、在异位妊娠组和妊娠终止组无变化(P>0.05)。最终分娩率先兆流产组(74.4%)低于正常妊娠组(92.0%)(P=0.001),围生期并发症发生率先兆流产组(31.3%)高于正常妊娠组(12.0%)(P=0.003)。结论:早期不良妊娠结局患者血清P、HCG和HPL水平均较同期正常孕妇显著下降,且不同类型患者同期水平也存在差异,联合检测此3项指标对不同类型早期不良妊娠者妊娠结局有一定预测价值。
Objective： To observe the changes of level of serum progesterone（P）, human chorionic gonadotropin（HCG） and human placental lactogen （HPL） of pregnant women, and to evaluate the predictive value of levels of P, HCG, and HPI. for adverse outcomes during early pregnant stage. Methods： 240 women with early adverse pregnancy in Dongfang maternity and child care hospital of Hainan province from October 2015 to October 2017 were included the study, which included 90 women with threatened abortion（in group A）, 90 women with early pregnancy termination （in group B） and 60 women with ectopic pregnancy （in group C）. At the same time, another 100 women with normal pregnancy were included into group D. The level of serum levels of serum P, HCG and HPL of all included women were detected at the sixth, seventh and eighth gestational week, and the changes of levels of serum P, HCG and HPL at different gestational week were analyzed and compared among the three groups. Results： The level of serum P, HCG and HPL had significant difference among the four groups （P〈0.05）, which included those in group A were significant lower than those in group D, those in group C were significant lower than those in group A, those in group C were significant lower than those in group A, and those in group B were significant lower than those in group C （P〈0.05）. The level of serum P had no significant difference among the four groups （P〉0.05）. The levels of HCG and HPL in group D and group A had significantly increased （P〈0.05）, and had no any change in group C and group B （P〉0.05）. The eventually delivery rate （74.4%, 67/90） in group A was significantly lower than that in group D （92%, 92/100） （χ^2 =10.692, P=0.001）, and perinatal complication rate in group A （31.3%, 21/67） was significantly higher than that in group D（12.0%, 11/92） （χ^2=9.06, P=0.003）. Conclusion： Level of serum P, HCG and HPL of pregnant women with early adverse pregnant outcomes are signific
作者
吉家安
符英萍
JI Jiaan;FU Yingping(Dongfang Maternity and Child Care Hospital of Hainan Province, Hainan, 57260)
出处
《中国计划生育学杂志》
2018年第6期500-503,共4页
Chinese Journal of Family Planning
关键词
孕酮
绒毛促性腺激素
胎盘生乳素
早期不良妊娠结局
预测
Progesterone
Human chorionic gonadotropin
Human placental lactogen
Adverse early pregnant outcomes
Prediction
