摘要
目的:了解某口腔专科医院(以下简称“该院”)门诊超说明书用药情况,为提高口腔专科医院合理用药水平提供参考。方法:收集2019年7月至2020年6月该院门诊处方中的超说明书用药信息,采用PASSPA2系统,按3%的比例随机抽取门诊处方,采用帕累托图及相关法则对超说明书用药处方进行回顾性统计分析。结果:共随机抽取该院门诊处方5153张,含用药医嘱9444条;其中,1393张处方存在超说明书用药,超说明书用药发生率为27.03%;3174条医嘱存在说明书用药,超说明书用药发生率为33.61%。超说明书用药类型的主要因素为超适应证;次要因素为超给药途径;一般因素为超适应人群、超用法与用量、超注意事项。结论:通过帕累托图对该院门诊超说明书用药处方进行分析,有利于明确该院门诊超说明书用药问题的主要因素和次要因素。针对这些因素,医疗机构应持续加强超说明书用药的管理,提高医院合理用药水平。
OBJECTIVE:To investigate the status of off-label drug use in outpatient department of a stomatological hospital(hereinafter referred to as"the hospital"),so as to provide reference for improving the level of rational drug use in stomatological hospital.METHODS:Off-label drug use information in outpatient prescriptions of the hospital from Jul.2019 to Jun.2020 was collected.PASSPA2 system was used to randomly select outpatient prescriptions according to the rate of 3%.Pareto chart and related rules were used to retrospectively analyze the prescriptions of off-label drug.RESULTS:Totally 5153 outpatient prescriptions were selected,including 9444 medical orders.There were 1393 prescriptions with off-label drug use,and the incidence of off-label drug use was 27.03%.There were3174 medical orders for off-label drug use,and the incidence was 33.61%.The main factors of off-label drug use were off-label indications.The secondary factors were the administration routes.The general factors were off-label population,off-label usage and dosage,and off-label precautions.CONCLUSIONS:Analysis of off-label drug use in the outpatient department of the hospital by Pareto chart is helpful to identify the main and secondary factors of off-label drug use in the outpatient department of the hospital.In response to these factors,medical institutions should continue to strengthen the management of off-label drug use and improve the level of rational drug use in hospitals.
作者
李丹丹
王建莉
徐亮
聂成
LI Dandan;WANG Jianli;XU Liang;NIE Cheng(Dept.of Pharmacy,West China Hospital of Stomatology Sichuan University,Sichuan Chengdu 610041,China;West China School of Pharmacy,Sichuan University,Sichuan Chengdu 610041,China)
出处
《中国医院用药评价与分析》
2021年第4期481-484,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
国家自然科学基金项目(No.21871190)。
关键词
超说明书用药
口腔专科医院
帕累托分析
Off-label drug use
Stomatological hospital
Pareto chart analysis
