摘要
目的探讨多西他赛联合卡铂治疗卵巢癌的效果及对免疫状态、血流参数的影响。方法选取2018年1月~2020年1月于广东省阳江市人民医院治疗的68例晚期卵巢癌患者作为研究对象,根据治疗方案不同将其分为观察组(35例)与对照组(33例)。观察组患者给予多西他赛联合卡铂治疗,对照组患者给予紫杉醇联合顺铂治疗。比较两组患者的疗效、免疫指标、血流参数、中位生存时间及不良反应。结果两组患者的疗效比较,差异无统计学意义(P>0.05)。观察组患者治疗后的CD3^(+)、CD4^(+)高于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后的动脉收缩期最大流速(PSV)低于对照组,血管阻力指数(RI)、搏动指数(PI)高于对照组,差异有统计学意义(P<0.05)。两组患者的中位生存时间、不良反应发生率比较,差异无统计学意义(P>0.05)。结论多西他赛联合卡铂治疗晚期卵巢癌有较好的效果,能明显改善患者免疫状况及卵巢血流动力学参数。
Objective To explore the effect of Docetaxel combined with Carboplatin in the treatment of ovarian cancer and its influence on immune status and blood flow parameters.Methods A total of 68 patients with advanced ovarian cancer treated in Yangjiang People′s Hospital from January 2018 to January 2020 were selected as the research objects and divided into the observation group(35 cases)and the control group(33 cases)according to the treatment plan,the observation group was treated with Docetaxel combined with Carboplatin,the control group was treated with Paclitaxel combined with Cisplatin.The efficacy,immune indexes,blood flow parameters,median survival time and adverse reactions of the two groups were compared.Results There was no statistically significant difference in the efficacy between the two groups(P>0.05).After treatment,CD3^(+),CD4^(+)in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the maximum systolic flow velocity(PSV)of the observation group was lower than that of the control group,while the vascular resistance index(RI)and pulse index(PI)of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in the median survival time and the incidence of adverse reactions between the two groups(P>0.05).Conclusion Docetaxel combined with Carboplatin has a good effect in the treatment of advanced ovarian cancer,which can significantly improve the immune status and ovarian hemodynamic parameters.
作者
罗蕙雨
张翠娟
林金凤
LUO Hui-yu;ZHANG Cui-juan;LIN Jin-feng(Department of Gynecology,Yangjiang People′s Hospital,Guangdong Province,Yangjiang529500,China)
出处
《中国当代医药》
CAS
2021年第11期17-20,25,共5页
China Modern Medicine
关键词
多西他赛
卡铂
卵巢癌
临床效果
免疫
血流参数
Docetaxel
Carboplatin
Ovarian cancer
Clinical effect
Immune
Hemodynamic parameters
