摘要
目的探讨中性粒细胞/淋巴细胞比值(NLR)与绝经后女性冠心病患者疾病严重程度的相关性。方法选取2016年1月-2019年12月到本院住院行冠状动脉造影绝经后女性340例,根据冠脉造影确诊为冠心病者216例,其中单支病变组100例,多支病变组116例,需要行冠状动脉介入(PCI)或冠状动脉旁路移植术(CABG)者96例(PCI组),不需要行PCI或CABG者120例(非PCI组),根据应激状态分为急性冠脉综合征组(ACS)92例和非ACS组124例,对照组124例。收集空腹血样本用于血常规、血脂、血糖、HbA_(1c)等检测。结果在绝经后女性人群中,冠心病组NLR明显高于对照组(P<0.05);冠脉多支病变组NLR水平高于单支病变组和对照组(P<0.05);PCI组NLR水平高于非PCI组和对照组(P<0.05);ACS组NLR水平高于非ACS组和对照组(P<0.05);Logistic回归分析提示NLR是ACS的独立危险因素(OR=2.832,P=0.005);ROC曲线分析发现,NLR的曲线下面积为0.811,其截断值取2.56时,诊断ACS的灵敏度为80.80%,特异度为71.20%。结论在绝经后女性冠心病患者中,NLR与冠心病严重程度密切相关。
Objective To investigate the relationship between neutrophil/lymphocyte ratio(NLR)and disease severity in postmenopausal women with coronary heart disease(CHD).Methods A total of 340 postmenopausal women with coronary artery angiography were enrolled in our hospital.According to coronary angiography,216 patients were diagnosed as CHD,including 100 patients with single-vessel disease and 116 patients with multi-vessel disease.There are 96 patients(the PCI group)who need PCI or CABG,and 120 patients(the non-PCI group)who do not need PCI or CABG.According to the stress state,patients with CHD were divided into the acute coronary syndrome(ACS)group and the non-acute coronary syndrome(non-ACS)group.The fasting blood samples were collected for blood routine,blood lipids,blood glucose,HbA_(1C).Results Postmenopausal women with CHD had higher NLR levels than those in the control group(P<0.05).The NLR levels in the coronary multi vessel disease group were higher than that in the single-vessel disease group and the control group(P<0.05).Postmenopausal women in the PCI group had higher NLR levels than those in the non-PCI group and the control group(P<0.05).The NLR levels in the ACS group were higher than those in the non-ACS group and the control group(P<0.05);Logistic regression analysis showed that NLR was an independent risk factor for ACS(OR=2.832,P=0.005);ROC curve analysis showed that the area under the curve of NLR was 0.811,and when the cutoff value was 2.56,the sensitivity of the diagnostic ACS was 80.80%,and the specificity was 71.20%.Conclusion NLR is closely related to the severity of CHD in postmenopausal women.
作者
吕浙棋
李晓岚
LV Zhe-qi;LI Xiao-lan(Internal Medicine-Cardiovascular Department,First People's Hospital of Tonglu County,Tonglu,Zhejiang 311500,China)
出处
《中国卫生检验杂志》
CAS
2021年第7期841-844,共4页
Chinese Journal of Health Laboratory Technology
关键词
中性粒细胞/淋巴细胞比值
冠心病
绝经后
Neutrophil/lymphocyte ratio
Coronary heart disease
Postmenopausal
