摘要
目的观察六神丸治疗流行性感冒(病毒快速抗原检测阳性,简称流感)的临床疗效。方法选取本院2018年11月—2019年5月的流感患者122例,随机分为治疗组和对照组,其中治疗组60例,对照组62例,治疗组给予六神丸治疗,对照组给予板蓝根颗粒治疗,患者体温>39.0℃时,可服用对乙酰氨基酚片,并记录服用量。在治疗第5天时评价患者的临床痊愈率、有效率,比较两组间病毒转阴率、单项症状改善情况、对乙酰氨基酚片使用情况、外周血实验室检查等。结果六神丸在治疗流感有效率上与板蓝根颗粒无统计学差异,但痊愈率优于板蓝根颗粒;在单项症状改善方面,六神丸在咽痛的改善方面优于板蓝根颗粒;六神丸也可以减少流感患者对乙酰氨基酚片的使用量;外周血实验室指标显示,治疗5 d后2组白细胞计数、中性粒细胞计数、淋巴细胞计数、中性粒细胞百分比和淋巴细胞百分比均恢复到正常范围。结论六神丸对于流感具有良好的疗效,其中在对于流感引起的炎症反应方面具有独特的效果,六神丸可以作为治疗流感的一个可行的治疗方案在临床上进一步的验证及推广。
Objective To compare the clinical observation of Liushen Pill(六神丸) in the treatment of influenza(positive virus rapid antigen detection). Methods A total of 122 cases of influenza patients in the Second Affiliated Hospital of Nanjing Medical University from November 2018 to May 2019 were randomly divided into treatment group and control group, 60 cases in the treatment group and 62 cases in the control group. The treatment group was treated with Liushen Pill and the control group was treated with Banlangen Granules(板蓝根颗粒), and when the temperature of patient was higher than 39.0 ℃, the patients could take acetyl aminophenol tablets and the dosage was recorded. The recovery rate of patients in the treatment group was compared with that in the control group on the day 5. Results There was no significant difference between Liushen Pill and Banlangen Granules in the effective rate of influenza treatment, but the cure rate of Liushen Pill was better than Banlangen Granules. In the improvement of single symptom, Liushen Pill was better than Banlangen Granules in improving pharyngitis. In addition, Liushen Pill could also reduce the use of acetyl aminophenol tablets in patients with influenza. The laboratory indexes of peripheral blood showed that after 5 d of treatment, the data of both groups, white blood cell count, neutrophil count, lymphocyte count, neutrophil percentage, and lymphocyte percentage were all returned to normal range. Conclusion Liushen Pill has good curative effect on influenza and unique effect on influenza-induced inflammatory reaction, which is a good proof as a feasible treatment for influenza and worth further verification and promotion in clinic.
作者
秦湧
QIN Yong(Department of Respiratory Medicine,Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China)
出处
《中草药》
CAS
CSCD
北大核心
2021年第6期1687-1691,共5页
Chinese Traditional and Herbal Drugs
关键词
六神丸
流行性感冒
随机对照
板蓝根颗粒
炎症反应
Liushen Pill
influenza
randomized control
Banlangen Granules
inflammatory response
