摘要
目的探讨聚乙二醇滴眼液联合重组牛碱性成纤维细胞生长因子眼用凝胶治疗睑板腺功能障碍型(MGD)干眼症的临床效果。方法选取2018年4月~2019年7月湖北省荆门市中医医院门诊就诊的311例(622眼)MGD干眼症患者作为研究对象,按照随机抽签方法将患者分为观察组(160例,320眼)和对照组(151例,302眼)。两组均予以重组牛碱性成纤维细胞生长因子眼用凝胶电导治疗,机械疏通睑板腺。观察组滴用聚乙二醇滴眼液4次/d,对照组隔日滴用聚乙二醇滴眼液。比较两组患者自觉症状评分、SchirmerⅠ试验(SⅠt)、泪膜破裂时间(BUT)、角膜荧光素染色评分、脂质性状评分。结果治疗前两组BUT、角膜荧光素染色和自觉症状评分比较,差异无统计学意义(P>0.05)。治疗后观察组BUT长于对照组,角膜荧光素染色和自觉症状评分低于对照组,差异有统计学意义(P<0.05)。治疗后两组的脂质性状评分低于治疗前,差异有统计学意义(P<0.05),而两组间比较,差异无统计学意义(P>0.05)。两组治疗前后SⅠt比较,差异无统计学意义(P>0.05)。两组治疗过程中均未发生明显不良反应。结论聚乙二醇滴眼液规范滴眼联合重组牛碱性成纤维细胞生长因子眼用凝胶治疗MGD干眼症临床效果好,安全性较高。
Objective To investigate the clinical effect of Polyethylene Glycol Eye Drops combined with Recombinant Bovine Basic Fibroblast Growth Factor Eye Gel in the treatment of meibomian gland dysfunction(MGD)xerophthalmia.Methods A total of 311 cases(622 eyes)of MGD patients with xerophthalmia who visited the outpatient department of Jingmen Traditional Chinese Medicine Hospital from April 2018 to July 2019 were selected as the research subjects.According to the random drawing method,the patients were divided into the observation group(160 cases,320 eyes)and the control group(151 cases,302 eyes).Two groups were treated with Recombinant Bovine Basic Fibroblast Growth Factor Eye Gel of conductance treatment,and the meibomian gland was mechanical dredged.The observation group was treated with Polyethylene Glycol Eye Drops 4 times/d,and the control group was treated with Polyethylene Glycol Eye Drops every other day.The patients′self-conscious symptom score,SchirmerⅠtest(SⅠT),tear film rupture time(BUT),corneal fluorescein staining score and lipid trait score were compared between the two groups.Results There were no significant differences in BUT,corneal fluorescein staining and conscious symptom scores between the two groups before treatment(P>0.05).After treatment,BUT in the observation group was longer than that in the control group,and the corneal fluorescein staining and conscious symptom score in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,lipid trait scores of the two groups were lower than those before treatment,and the difference was statistically significant(P<0.05).There was no significant difference in SⅠT between the two groups before and after treatment(P>0.05).There were no obvious adverse reactions in the two groups during the process of the treatment.Conclusion The clinical effect of standard Polyethylene Glycol Eye Drops combined with Recombinant Bovine Basic Fibroblast Growth Factor Eye Gel for the treatm
作者
康斌
万金兰
KANG Bin;WAN Jin-lan(Department of Ophthalmology,Jingmen Traditional Chinese Medicine Hospital,Hubei Province,Jingmen448000,China)
出处
《中国当代医药》
CAS
2021年第8期115-118,共4页
China Modern Medicine
基金
湖北省卫生健康委员会科研项目(WJ2019F114)。
关键词
干眼症
睑板腺功能障碍
联合治疗
临床效果
Xerophthalmia
Meibomian gland dysfunction
Combined treatment
Clinical effect
