摘要
目的分析儿童原发性肾病综合征(primary nephritic syndrome,PNS)发生高尿酸血症(hyperuricemia,HUA)的相关因素。方法选取2019年1—12月本院收治的85例PNS患儿作为观察组,选择同时期85例健康体检的儿童作为对照组,检测血尿酸、生化指标[血清白蛋白、血肌酐、三酰甘油、总胆固醇、高密度脂蛋白、低密度脂蛋白、脂蛋白(a)、高敏C反应蛋白、同型半胱氨酸]水平。依据血尿酸水平将患儿分为HUA组和NUA组(尿酸正常),调查PNS患儿HUA的发生率和相关因素。结果观察组的血尿酸水平、HUA发生率均高于对照组(P<0.05),两组生化指标比较差异均有统计学意义(P<0.05);PNS患儿中HUA患儿16例、NUA患儿69例,HUA组血清白蛋白水平低于NUA组,血肌酐、三酰甘油和总胆固醇水平均高于NUA组,比较差异均统计学意义(P<0.05);血尿酸水平与血清白蛋白水平呈负相关,与血肌酐、三酰甘油、总胆固醇呈正相关(P<0.05)。结论PNS患儿HUA的发生与血尿酸的水平密切相关,临床医生应该进行重视。
Objective To analyze the related factors of hyperuricemia(HUA)in children with primary nephrotic syndrome(PNS).Methods 85 children with PNS admitted to our hospital from January to December 2019 were selected as the observation group,and 85 healthy children during the same period were selected as the control group,serum uric acid and biochemical indicators[serum albumin,serum creatinine,triacylglycerol,total cholesterol,high-density lipoprotein,lowdensity lipoprotein,lipoprotein(a),high sensitivity C-creative protein,homocysteine]levels were detected.According to the serum uric acid level,the PNS patients were divided into HUA group and NUA group(normal uric acid),and the incidence and related factors of HUA in children with PNS were explored.Results The serum uric acid level in the observation group was higher than that in the control group,and the incidence of HUA in the observation group was higher than that in the control group(P<0.05).The difference in biochemical indicators between the two groups was statistically significant(P<0.05).Among the children with PNS,there were 16 children with HUA and 69 children with NUA.The serum albumin level of the HUA group was lower than NUA group,and the serum creatinine,triacylglycerol and total cholesterol were higher than that of the NUA group,the difference were statistically significant(P<0.05).Serum uric acid levels were negatively correlated with serum albumin levels,and positively correlated with serum creatinine,triacylglycerol,and total cholesterol(P<005).Conclusion The occurrence of HUA in children with PNS is closely related to the level of serum uric acid,and clinicians should pay attention to it.
作者
杨于恩
YANG Yu’en(Department of Pediatrics,The 900th Hospital of Chinese People's Liberation Army Joint Logistics Support Force,Fuzhou Fujian 350025,China)
出处
《中国卫生标准管理》
2021年第4期14-16,共3页
China Health Standard Management
关键词
儿童原发性肾病综合征
高尿酸血症
血尿酸
相关因素
肌酐
三酰甘油
children's primary nephrotic syndrome
hyperuricemia
serum uric acid
related factors
creatinine
triacylglycerol
