摘要
目的探究不同年龄段的成年肾病综合征(nephrotie syndrome,AS)患者血清肌酐、尿素氮含量与尿酸水平的关联性,以期为尿酸代谢预防以及控制提供理论依据。方法采用分层随机抽样的方法选择2018年3月至2020年8月在南充市中心医院门诊确诊为肾病综合征的不同年龄段个体作为研究对象,同时选择同期体检的健康个体300例作为健康对照组。研究对象年龄范围为18~55岁。回顾性收集不同年龄段患者血清肌酐、尿素氮以及尿酸等生化检测结果。Pearson相关分析成人血清肌酐、尿素氮表达与和尿酸水平相关性。结果健康成年群体肌酐、尿素氮水平于18~40岁呈现上升趋势,至40岁达到平台期;而尿酸水平随着年龄增长呈上升趋势。不同年龄段的AS患者的血清肌酐、尿素氮与尿酸水平均高于健康对照组,且45~55岁期间上升最为明显。t检验结果显示,除18~20岁年龄段,其他年龄段健康对照组的血清肌酐、尿素氮与尿酸含量均与AS患者存在差异。主要表现为,AS患者测量值高于健康对照组。采用Pearson相关分析不同年龄段AS患者血清肌酐、尿素氮水平与尿酸的关联性,结果显示,41~45岁年龄段患者肌酐水平与尿酸相关性最强,r为0.584;51~55岁年龄段患者尿素氮水平与尿酸相关性最强,r为0.373。将AS患者血清肌酐、尿素氮与尿酸含量存在相关性的年龄段依据性别进行亚组分层,结果显示,36~40岁、41~45岁年龄段男性、女性AS患者的肌酐含量均与尿酸存在显著正相关(r>0.45,P<0.05);同时,21~25岁、51~55岁年龄段女性AS患者的尿素氮与尿酸水平存在一定相关性(r>0.30,P<0.05)。结论36~45岁年龄段的肾病综合征患者血清肌酐表达水平可有效预测尿酸水平,且女性群体预测价值高于男性。
Objective To explore the correlation between serum creatinine,blood urea nitrogen content and uric acid level in adult nephrotie syndrome(AS)patients of different ages,in order to provide a theoretical basis for the prevention and control of uric acid metabolism.Methods Individuals of different ages who were diagnosed with nephrotic syndrome from March 2018 to August 2020 in the outpatient department of our hospital were selected as research subjects by stratified random sampling,healthy individuals who underwent physical examination during the same period were selected as controls.The age range of the subjects was 18-55 years old.The biochemical test results of serum creatinine,blood urea nitrogen and uric acid were retrospectively collected from patients of different ages.Pearson correlation analysis of adult serum creatinine,blood urea nitrogen and uric acid levels.Results The levels of creatinine and blood urea nitrogen in healthy adults showed an upward trend at the age of 18-40,and reached a plateau at the age of 40;while the level of uric acid showed an upward trend with age.The levels of serum creatinine,blood urea nitrogen and uric acid in AS patients at different ages were higher than those in healthy controls,and the increase was most pronounced between the ages of 45 and 55.The t-test results showed that the serum creatinine,blood urea nitrogen and uric acid contents of healthy controls were different from those of AS patients except for the 18-22 age group.The main performance was that AS patients had higher measured values than healthy controls.Pearson correlation was used to analyze the correlation between serum creatinine and blood urea nitrogen levels and uric acid in AS patients of different ages.The results showed that the 41-45-year-old patients had the strongest correlation with uric acid,r was 0.584;The patients′blood urea nitrogen level had the strongest correlation with uric acid,with r of 0.373.The age groups with the correlation between serum creatinine,blood urea nitrogen and uric aci
作者
张鸿
邓川
余佳珍
崔学丽
ZHANG Hong;DENG Chuan;YU Jia-zhen;CUI Xue-li(Department of Laboratory,Nanchong Central Hospital,Nanchong,Sichuan 637000,China)
出处
《公共卫生与预防医学》
2023年第1期109-112,共4页
Journal of Public Health and Preventive Medicine
关键词
成年人
肾病综合征
肌酐
尿素氮
尿酸
Aadults
Nephrotic syndrome
Creatinine
Urea nitrogen
Uric acid
