摘要
目的研究依托考昔治疗急性痛风性关节炎的疗效及安全性。方法选择2016年8月至2017年12月在郑州市骨科医院收治的急性痛风性关节炎患者80例。按照随机数指标法分为观察组与对照组,每组40例。两组均予以卧床、局部冷敷等对症治疗,在此基础上观察组予以依托考昔治疗,对照组予以双氯芬酸钠治疗。用药1周后对比两组治疗效果、症状改善时间,并记录治疗过程中出现的不良反应。结果观察组治疗总有效率为80%(32/40),显著高于对照组(57.5%,23/40),差异有统计学意义(χ2=4.713,P<0.05)。治疗1周后,观察组临床症状改善情况优于对照组,差异有统计学意义(P<0.05)。治疗1周后,观察组血小板(PLT)、尿酸(UA)、白细胞(WBC)、血沉(ESR)、C反应蛋白(CRP)及血清肌酐(Scr)水平改善情况均优于对照组,差异有统计学意义(P<0.05)。观察组治疗期间不良反应发生率为5%(2/40),对照组不良反应发生率为12.5%(5/40),两组比较差异有统计学意义(P<0.05)。结论依托考昔对急性痛风性关节炎疗效确切,且不良反应发生率低,与传统非甾体抗炎药(NSAIDs)药物相比更加有效,安全性高,值得临床应用推广。
Objective To study the therapeutic effect of etocoxib on acute gouty arthritis and its safety.Methods From August 2016 to December 2017,80 patients with acute gouty arthritis were enrolled in Zhengzhou orthopedic hospital.According to the random number index method,the patients were divided into observation group and control group,with 40 cases in each group.Both groups were given bed rest,local cold compress and other symptomatic treatment.On this basis,the observation group was treated by etoricoxib,while the control group was treated by diclofenac sodium.One week later,the treatment effects and symptom improvement time of the two groups were compared,and the adverse reactions during the treatment were recorded.Results The total effective rate of the observation group was80%(32/40),which was significantly higher than that of the control group(57.5%,23/40),the difference was significant(χ2=4.713,P<0.05).After one week of treatment,the improvement of clinical symptoms in the observation group was better than that in the control group,the difference was significant(P<0.05).After one week of treatment,the improvement of platelet(PLT),uric acid(UA),leukocytes(WBC),ESR,C-reactive protein(CRP)and serum creatinine(Scr)in the observation group were better than those in the control group,the differences were significant(P<0.05).The incidence of adverse reactions was 5%(2/40)in the observation group and 12.5%(5/40)in the control group,the difference between the two groups was significant(P<0.05).Conclusions Compared with the traditional NSAIDs,etocoxib is more effective and safe,which is worthy of clinical application and promotion.
作者
陈琼
Chen Qiong(Department of Pharmacy,Zhengzhou Orthopaedic Hospital,Zhengzhou 450052,China)
出处
《临床医学》
CAS
2020年第2期111-113,共3页
Clinical Medicine
