摘要
背景新生儿持续肺动脉高压为临床常见疾病,严重时甚至可导致新生儿死亡,是危害新生儿生命安全的重要危险因素,因而及时开展有效治疗对改善患儿预后有十分重要的意义。目的探讨小剂量多巴胺、多巴酚丁胺静脉滴注联合高频振荡通气治疗新生儿持续肺动脉高压的临床疗效。方法选取深圳市福田区妇幼保健院2016年1月—2019年1月收治的新生儿持续肺动脉高压患儿70例为研究对象。采用随机数字表法将患儿分为对照组和观察组,各35例。对照组患儿在常规治疗的基础上行高频振荡通气治疗,观察组患儿在对照组治疗的基础上采用小剂量多巴胺、多巴酚丁胺静脉滴注。比较两组患儿临床疗效,治疗前后血气分析指标〔包括动脉血氧分压(PaO2)、动脉血氧饱和度(SaO2)、动脉血二氧化碳分压(PaCO2)〕、脑钠肽(BNP)、C反应蛋白(CRP),呼吸机使用时间及治疗前后肺动脉收缩压(PASP)。结果观察组患儿临床疗效优于对照组(P<0.05)。观察组患儿治疗后PaO2、SaO2高于对照组,PaCO2低于对照组(P<0.05)。观察组患儿治疗后BNP、CRP低于对照组(P<0.05)。观察组患儿呼吸机使用时间短于对照组,治疗后PASP低于对照组(P<0.05)。两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论小剂量多巴胺、多巴酚丁胺静脉滴注联合高频振荡通气治疗新生儿持续肺动脉高压患儿的临床疗效确切,可有效改善患儿病情,促进血气分析指标的恢复,降低BNP、CRP及肺动脉压,缩短呼吸机使用时间,且有较好的安全性,可在临床上推广应用。
Background Neonatal persistent pulmonary hypertension is a common clinical disease.In severe cases,it can even lead to death of newborns and is an important risk factor endangering the life safety of newborns.Therefore,effective treatment in time is of great significance to improve the prognosis of children.Objective To investigate the clinical efficacy of intravenous drip of low dose dopamine and dobutamine combined with high frequency oscillatory ventilation in the treatment of neonatal persistent pulmonary hypertension.Methods A total of 70 cases of neonatal persistent pulmonary hypertension admitted to Women&Children Health Institute Futian Shenzhen from January 2016 to January 2019 were selected as the research objects.The children were divided into control group and observation group according to random number table method,with 35 cases in each group.Children in the control group were treated with high frequency oscillatory ventilation on the basis of conventional treatment,and children in the observation group received intravenous infusion of low dose dopamine and dobutamine on the basis of the control group.The clinical efficacy,blood gas analysis indicators〔including arterial partial pressure of oxygen(PaO2),arterial oxygen saturation(SaO2),arterial partial pressure of carbon dioxide(PaCO2)〕,brain natriuretic peptide(BNP)and C-reactive protein(CRP)before and after treatment,ventilator use time and pulmonary artery systolic pressure(PASP)before and after treatment were compared between the two groups.Results The clinical efficacy of the observation group was better than that of the control group(P<0.05).After treatment,PaO2 and SaO2 of the observation group were higher than those of the control group,and PaCO2 was lower than that of the control group(P<0.05).BNP and CRP of children in the observation group were lower than those in the control group after treatment(P<0.05).The ventilator use time of the observation group was shorter than that of the control group,and PASP after treatment was lower than
作者
陈尊
刘芳
邓健
CHEN Zun;LIU Fang;DENG Jian(Department of Paediatrics,Women&Children Health Institute Futian Shenzhen,Shenzhen 518045,China)
出处
《实用心脑肺血管病杂志》
2021年第3期101-105,共5页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
肺动脉高压
婴儿
新生
多巴胺
多巴酚丁胺
高频振荡通气
治疗结果
Pulmonary arterial hypertension
Infant,newborn
Dopamine
Dobutamine
High-frequency oscillation ventilation
Treatment outcome
