摘要
目的:分析和比较酚妥拉明联合多巴酚丁胺与多巴胺治疗重症肺炎患儿的有效性及安全性。方法:选取2014年4月至2019年4月西安交通大学附属儿童医院急诊科收治的96例重症肺炎患儿,根据入院单双号将其分为对照组(n=48)和研究组(n=48)。对照组接受多巴酚丁胺与小剂量多巴胺治疗,研究组在对照组的基础上联合酚妥拉明治疗。比较两组的治疗总有效率、治疗前后各血气指标与炎性因子水平变化以及不良反应的发生情况。结果:治疗后,研究组总有效率显著高于对照组(93.75%vs.79.17%,P<0.05);两组的血气指标PaO2、SaO2均显著升高,PaCO2显著降低,且研究组的变化比对照更加显著(P<0.05);两组各的炎性因子水平IL-6、IL-8、CRP和TNF-α均显著降低,且研究组显著低于对照组(P<0.05)。两组不良反应发生率比较无统计学差异(P>0.05)。结论:酚妥拉明联合多巴酚丁胺治疗重症肺炎患儿的临床疗效明显优于酚妥拉明联合多巴胺治疗,且二者安全性相当。
Objective:Analysis and comparison of the efficacy and safety of phenolamine combined with dobutamine and dopamine in the treatment of children with severe pneumonia.Methods:96 children with severe pneumonia admitted to the emergency department of Children’s Hospital of Xi’an Jiaotong University from April 2014 to April 2019 were selected.The subjects were divided into the control group(n=48)and the study group(n=48)according to the number of single and even number of admission.The control group received dobutamine and low dose of dopamine,and the study group received combined phenolamine treatment on the basis of the control group.The total effective rate,the changes of blood gas indexes and inflammatory factor levels before and after treatment,and the incidence of adverse reactions were compared between the two groups.Results:After treatment,the total effective rate of treatment in the study group was significantly higher than that in the control group(93.75%vs.79.17%,P<0.05).The blood gas indexes PaO2 and SaO2 of the two groups were significantly increased,PaCO2 was significantly decreased,and the change of the study group was more significant than the control group(P<0.05).The levels of inflammatory factors IL-6,IL-8,CRP and TNF-αwere significantly lower in the two groups,and the study group was significantly lower than the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The clinical efficacy of phentolamine combined with dobutamine in the treatment of children with severe pneumonia is significantly better than phentolamine combined with dopamine treatment,and the safety of the two is equivalent.
作者
邹宗毅
闫黎娜
陈镜
李明月
郭彦孜
ZOU Zong-yi;YAN Li-na;CHEN Jing;LI Ming-yue;GUO Yan-zi(Department of Emergency,Children's Hospital Affiliated to Xi'an Jiaotong University,Xi'an,Shaanxi,710003,China;Department of Neonatology,Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang,Shaanxi,712000,China)
出处
《现代生物医学进展》
CAS
2019年第24期4703-4706,共4页
Progress in Modern Biomedicine
基金
陕西省卫生健康委科研基金项目(2018D005).
