摘要
目的探讨高频振荡通气联合西地那非治疗新生儿持续性肺动脉高压(PPHN)的效果。方法选取2020年1月至2021年12月平邑县人民医院收治的80例PPHN新生儿作为研究对象,采用奇偶数法分为研究组与对照组,每组40例。对照组采用高频振荡通气治疗,研究组采用高频振荡通气联合西地那非治疗。比较两组临床疗效、血气指标及不良反应发生率。结果研究组治疗总有效率为92.50%,高于对照组的72.50%,差异有统计学意义(P<0.05)。治疗后,两组动脉血氧分压(PaO_(2))、动脉血氧饱和度(SaO_(2))水平均高于治疗前,动脉血二氧化碳分压(PaCO_(2))水平低于治疗前,且研究组PaO_(2)、SaO_(2)水平均高于对照组,PaCO_(2)水平低于对照组,差异有统计学意义(P<0.05)。治疗后,两组肺动脉压(PAP)均低于治疗前,心率(HR)均慢于治疗前,且研究组PAP低于对照组,HR慢于对照组,差异有统计学意义(P<0.05),而两组治疗前后体循环血压(SBP)组内及组间比较差异无统计学意义。两组不良反应发生率比较差异无统计学意义。结论高频振荡通气联合西地那非治疗PPHN效果佳,可改善血气指标,且不增加不良反应发生风险。
Objective To investigate the efficacy of high-frequency oscillatory ventilation combined with sildenafil in the treatment of persistent pulmonary hypertension in newborns(PPHN).Methods 80 PPHN admitted to People's Hospital of Pingyi County from January 2020 to December 2021 were selected as the research subjects,and they were divided into the study group and the control group acorrding to odd even number grouping method,with 40 cases in each group.The control group received high-frequency oscillatory ventilation treatment,while the study group received high-frequency oscillatory ventilation combined with sildenafil treatment.The clinical efficacy,blood gas indicators,and incidence of adverse reac-tions were compared between the two groups.Results The total effective rate of treatment in the study group was 92.50%,which was higher than 72.50%in the control group,with difference was statistically significant(P<0.05).After treatment,the levels of arterial partial pressure of oxygen(PaO_(2))and arterial oxygen saturation(SaO_(2))of the two groups were higher than before treatment,the level of arterial carbon dioxide partial pressure(PaCO_(2))of the two groups were lower than before treatment,and the levels of PaO_(2),SaO_(2)in the study group were higher than those in the control group,the level of PaCO_(2)in the study group was higher than that in the control group,the differences were statistically significant(P<0.05).After treatment,the the levels of pulmonary artery pressure(PAP)of the two groups were lower than before treatment,and heart rate was slower than be-fore treatment,and PAP in the study group was lower than that in the control group,and heart rate was slower than that in the control group,the dif-ferences were statistically significant(P<0.05),but there was no significant difference in systemic blood pressure(SBP)between the two groups and within groups before and after treatment.There was no statistically significant difference in incidence of adverse reactions between the two groups.Conclusion The co
作者
李晓琳
李举
郭磊
LI Xiaolin;LI Ju;GUO Lei(Department of Neonatology,People's Hospital of Pingyi County,Linyi,Shandong,273300,China)
出处
《当代医学》
2024年第4期74-77,共4页
Contemporary Medicine
关键词
新生儿
持续性肺动脉高压
高频振荡通气
西地那非
疗效
不良反应
Newborn
Persistent pulmonary hypertension
High-frequency oscillation ventilation
Sildenafil
Efficacy
Adverse reactions
