摘要
目的:探讨不同正畸治疗措施对错[牙合]畸形患者龈沟液趋化因子CX3CL1、核因子κB受体活化因子配体/骨保护素(RANKL/OPG)水平的影响。方法:随机将96例拟采取正畸治疗的错[牙合]畸形患者分为4组,所有患者均采用方丝弓矫治器治疗,分别给予0、50、150、250 g的远中正畸力。观察4组患者治疗1、2、3、4周后龈沟液中CX3CL1、RANKL/OPG水平。采用SPSS 25.0软件包对数据进行统计学分析。结果:4组患者治疗1~3周后,龈沟液中CX3CL1、RANKL、RANKL/OPG水平持续上升,治疗4周后出现下降(P<0.05);治疗1~3周后,龈沟液中OPG处于较低水平,治疗4周后出现上升(P<0.05)。龈沟液中CX3CL1、RANKL、OPG、RANKL/OPG水平在A、B、C、D组逐渐增高(P<0.05),各组间相比,差异均有统计学意义(P<0.05)。结论:龈沟液中CX3CL1、RANKL/OPG水平与正畸力度和治疗时间关系密切,其动态水平变化可作为评估正畸治疗牙槽骨改建的重要指标。
PURPOSE:To investigate the effects of different orthodontic treatments on gingival crevicular fluid chemokine CX3 CL1,nuclear factorκB receptor activating factor ligand/osteoprotegerin(RANKL/OPG)levels in patients with malocclusion.METHODS:Ninety-six patients with malocclusion who were scheduled to undergo orthodontic treatment were randomly divided into four groups.All patients were treated with square wire appliance,and 0,50,150,250 g of fardistal orthodontic force were given respectively.The levels of CX3 CL1 and RANKL/OPG in gingival crevicular fluid were detected in four groups after 1,2,3,and 4 weeks of treatment.SPSS 25.0 software package was used for statistical analysis of the date.RESULTS:The levels of CX3 CL1,RANKL and RANKL/OPG in the gingival crevicular fluid of the four groups were continuously increased after treatment for 1-3 weeks,and decreased after 4 weeks of treatment(P<0.05).The OPG in the gingival crevicular fluid was at a low level after 1-3 weeks of treatment.There was an increase after 4 weeks of treatment(P<0.05).The levels of CX3 CL1,RANKL,OPG and RANKL/OPG in gingival crevicular fluid increased gradually in group A,B,C and D(P<0.05),and the differences between the groups were statistically significant(P<0.05).CONCLUSIONS:The levels of CX3 CL1 and RANKL/OPG in gingival crevicular fluid are closely related to orthodontic force and treatment time,and can be used as an index to evaluate orthodontic treatment of alveolar bone remodeling.
作者
林嘉旭
张汝弘
张健娜
巫晓平
LIN Jia-xu;ZHANG RU-hong;ZHANG Jian-na;WU Xiao-ping(Department of Stomatology,Shantou Central Hospital,Shantou 515000,Guangdong Province,China)
出处
《上海口腔医学》
CAS
北大核心
2021年第1期85-88,共4页
Shanghai Journal of Stomatology
