摘要
目的探讨龈沟液巨噬细胞炎症蛋白-1α(MIP-1α)及肿瘤坏死因子-α(TNF-α)与慢性牙周炎病情及疗效的关系。方法选取慢性牙周炎患者52例为实验组,选取同期30例健康人群为对照组。实验组行牙周基础治疗(全口龈上洁治术和龈下刮治术),并进行口腔卫生宣教,对照组只检查GI、BI、PG、AL,不进行任何治疗。比较2组患者治疗前后的龈沟液MIP-1α与TNF-α的含量及其与牙龈指数(GI)、出血指数(BI)、探针深度(PD)的相关性。结果实验组患者治疗前GI、BI等临床指标均显著高于对照组(P<0.05);实验组治疗后显效患者的GI、BI等临床指标显著低于对照组(P<0.05);龈沟液MIP-1α与TNF-α与患者临床指标具有显著相关性(P<0.05);实验组治疗后显效患者的龈沟液MIP-1α与TNF-α的含量显著低于实验组治疗前(P<0.05)。结论龈沟液MIP-1α及TNF-α与牙周炎临床指标具有相关性。
Objective To explore the relationship between macrophage inflammation protein-1α（ MIP-1α） as well as tumor necrosis factor-α（ TNF-α） in gingival sulcus fluid and chronic periodontitis and its curative efficacy. Methods A total of 52 chronic periodontitis patients in our hospital were selected as experimental group and 30 healthy subjects were selected as control group. The experimental group received basic periodontal treatment（ supragingival scaling and subgingival curettage） and oralhealth education while the control group was only given GI,BI,PG,AL examination without any treatment. The correlation between contents of MIP-1α as well as TNF-α in gingival sulcus fluid before and after treatment in two groups and the gingival indicators（ GI）,bleeding index（ BI）,and the depth of the probe（ PD） were explored. Results Before treatment,the GI,BI and other clinical indicators of experimental group were higher than that in the control group（ P〈0. 05）.The GI,BI and other clinical indicators of effective patients in the experimental group were lower than that of the control group after treatment（ P〈0. 05）. MIP-1α as well as TNF-α in gingival sulcus fluid were significantly correlated with clinical indicators（ P〈0. 05）. After treatment,the content of MIP-1α as well as TNF-α in gingival crevicular fluid in the experimental group were lower than treatment before（ P〈0. 05）. Conclusion MIP-1α as well as TNF-α in gingival crevicular fluid are correlated with periodontal clinical indicators.
作者
黄怀荣
胡凡荣
HUANG Huairong HU Fanrong(Periodontal Department Department of Children Stomatology, Xiamen Stomatological Hospital, Xiamen, Fujian, 361003)
出处
《实用临床医药杂志》
CAS
2017年第17期42-44,共3页
Journal of Clinical Medicine in Practice
基金
福建省卫生厅科研课题(1300251023)
关键词
巨噬细胞炎症蛋白-1Α
肿瘤坏死因子-Α
牙周炎
疗效
macrophage inflammation protein-1α
tumor necrosis factor-α
periodontitis
curative effect
