摘要
背景:在临床正畸矫正过程中,自锁托槽较传统托槽更加有利于牙周健康的维护,但以往的研究多局限于牙周临床指数和牙周致病菌方面,炎性因子是否参与其中尚未见相关报道。目的:对比自锁托槽与传统托槽矫治器矫治前后龈沟液内白细胞介素1β和肿瘤坏死因子α表达水平的变化。方法:选择需做固定矫治且牙周健康的38例患者为受试对象,其中男20例,女18例,年龄11-25岁,按照随机数字表法分为对照组和试验组,每组19例,分别采用传统托槽矫治器与自锁托槽矫治器进行矫治。在矫治前、矫治后4,8,12周检测龈沟液量及其中白细胞介素1β和肿瘤坏死因子α表达水平。结果与结论:两组矫治后的龈沟液量、白细胞介素1β和肿瘤坏死因子α水平均高于矫治前(P<0.05);试验组矫治后不同时间点的龈沟液量、白细胞介素1β和肿瘤坏死因子α表达水平低于对照组(P<0.05),表明自锁托槽矫治器更加有利于保护牙周组织的健康。
BACKGROUND： During clinical orthodontic correction, the self-ligating bracket is more helpful to maintain the periodontal healthy than the traditional bracket, but previous studies mainly focused on the clinical periodontal index and periodontal pathogens, and whether inflammatory cytokines are involved has not been reported. OBJECTIVE： To analyze the changes of the expression levels of interleukin 1β and tumor necrosis factor α in gingival crevicular fluid before and after the correction using self-ligating bracket and conventional bracket appliance. METHODS： Totally 38 orthodontic patients without periodontal disease（including 20 males and 18 females; aged 11-25 years） were included in this study. All the patients were randomly divided into control and test groups（n=19/group） and subjected to orthodontic correction using self-ligating bracket and conventional bracket appliance, respectively. The volumes of gingival crevicular fluid and expression levels of interleukin-1β and tumor necrosis factor-α were detected before correction and at 4, 8 and 12 weeks after correction.RESULTS AND CONCLUSION： The volume of gingival crevicular fluid and expression levels of interleukin-1β and tumor necrosis factor-α after correction were all higher than those before correction（P〈0.05）. The volume of gingival crevicular fluid and expression levels of interleukin-1β and tumor necrosis factor-α after correction in the test group were lower than those in the control group（P〈0.05）. These results demonstrate that self-ligating bracket appliance is more conducive to protect the periodontal tissue than the conventional bracket appliance.
出处
《中国组织工程研究》
CAS
北大核心
2015年第52期8428-8432,共5页
Chinese Journal of Tissue Engineering Research
基金
河北省科技计划项目(132077116D)~~
