摘要
目的了解湖北省全人群乙型病毒性肝炎(简称乙肝)免疫水平,为制定乙肝的预防控制策略提供依据。方法采用多阶段分层随机抽样方法,于2015—2018年选取湖北省8个市(15个县、45个社区)开展全人群乙肝表面抗原(HBsAg)和乙肝表面抗体(HBsAb)水平监测。结果湖北省全人群HBsAg携带率为2.67%、HBsAb阳性率为66.08%;HBsAg携带率和HBsAb阳性率在地区(HBsAg:χ^2=60.430,P=0.000;HBsAb:χ^2=215.599,P=0.000)、年龄(HBsAg:χ^2=109.341,P=0.000;HBsAb:χ^2=265.578,P=0.000)、职业(HBsAg:χ^2=70.919,P=0.000;HBsAb:χ^2=480.782,P=0.000)、免疫史(HBsAg:χ^2=36.725,P=0.000;HBsAb:χ^2=27.653,P=0.000)之间差异均有统计学意义;20岁以上(≥5.64%)、工人(7.59%)、农民(5.99%)和服务人员(5.45%)人群HBsAg携带率偏高,7~14岁(57.06%)、农民(58.98%)、学生(60.71%)和工人(60.76%)HBsAb阳性率偏低。结论湖北省乙肝防控取得一定成绩,但仍需加大宣传教育力度,提高重点人群(20岁以上、工人、农民、服务人员和学生)乙肝疫苗接种率,开展补充免疫等,有利于降低乙肝感染风险。
Objective To investigate the immunization level of hepatitis B among population in Hubei Province,and to provide a basis for developing strategies for hepatitis B prevention and control.Methods Hepatitis B surface antigen(HBsAg)and hepatitis B surface antibody(HBsAb)levels were monitored in 8 cities(including 15 counties and 45 communities)selected by using a multi-stage stratified random sampling method in Hubei Province from 2015 to 2018.Results HBsAg carrier rate and the positive rate of HBsAb in population in Hubei Province were 2.67%and 66.08%,respectively.There were statistically significant differences in HBsAg carrier rate and the positive rate of HBsAb among areas(HBsAg:χ^2=60.430,P=0.000;HBsAb:χ^2=215.599,P=0.000),ages(HBsAg:χ^2=109.341,P=0.000;HBsAb:χ^2=265.578,P=0.000),occupations(HBsAg:χ^2=70.919,P=0.000;HBsAb:χ^2=480.782,P=0.000)and immunization history(HBsAg:χ^2=36.725,P=0.000;HBsAb:χ^2=27.653,P=0.000).HBsAg carrier rate was found to be higher in people aged above 20 years(≥5.64%),workers(7.59%),farmers(5.99%)and service workers(5.45%).The positive rate of HBsAb was found to be lower in young people aged 7-14 years(57.06%),farmers(58.98%),students(60.71%)and workers(60.76%).Conclusions Hepatitis B prevention and control in Hubei Province has made certain achievements,but it is still necessary to implement intervention measures like increasing publicity and education,improving the vaccination rate of hepatitis B vaccine in the key population(including people aged above 20 years,workers,farmers,service workers and students)and carrying out supplementary immunization,which are conducive to reducing the risk of hepatitis B infection.
作者
骆金俊
王四全
王雷
赵明江
LUO Jin-jun;WANG Si-quan;WANG Lei;ZHAO Ming-jiang(Hubei Provincial Center for Disease Control and Prevention,Wuhan,Hubei 430079,China)
出处
《实用预防医学》
CAS
2021年第1期66-69,共4页
Practical Preventive Medicine
关键词
乙型病毒性肝炎
乙肝表面抗原
乙肝表面抗体
免疫水平
监测
hepatitis B
hepatitis B surface antigen
hepatitis B surface antibody
immunization level
surveillance
