摘要
[背景]双酚A(BPA)作为一种典型的环境内分泌干扰物,可能影响儿童体格发育。幼儿期是体格发育的关键期,可能对BPA暴露的潜在风险更为易感。[目的]了解山东莱州湾地区2岁幼儿尿BPA水平及其对儿童早期体格发育的影响。[方法]以山东莱州湾出生队列中参与随访的2岁幼儿为研究对象,共采集219名幼儿尿液并检测尿液中BPA水平,采用问卷收集母亲人口学信息、孕期健康影响因素以及幼儿基本信息和膳食信息,现场测量并记录幼儿身长、体重、头围、胸围,计算体重指数(BMI)。将BPA暴露水平按四分位数分为Q1~Q4,采用广义线性模型分析BPA暴露与体格发育的关联,并按性别分层分析。[结果]2岁幼儿尿液BPA质量浓度中位数为0.26μg·L^-1,肌酐校正值为1.07μg·g^-1。广义线性模型结果显示,幼儿BPA暴露水平与胸围呈正相关趋势(b=0.152,95%CI:0.028~0.275,P趋势=0.016)。与CQ1组相比,Q2、Q3组幼儿身长、体重出现下降(P<0.05),Q2组身长、体重下降值及其95%CI分别为1.29(2.25~0.32)cm、0.49(0.94~0.03)kg,Q3组身长、体重下降值及其95%CI分别为1.32(2.30~0.35)cm、0.49(0.95~0.03)kg,但趋势性检验无统计学意义(P趋势>0.05),其他指标变化无统计学意义。性别分层后,与Q1组男童相比,Q2组男童身长、体重、BMI下降(P<0.05),Q3组所有体格指标均下降(P<0.05);但男童BPA暴露水平与各指标趋势性检验均无统计学意义(P趋势>0.05)。与Q1组女童相比,Q2、Q4组女童BMI增加(P<0.05),但BPA暴露水平与女童BMI值之间无相关趋势;女童BPA暴露水平与胸围呈正相关趋势(b=0.173,95%CI:0.012~0.333,P趋势=0.035),但与身长、体重、头围未发现关联(P趋势>0.05)。[结论]2岁幼儿尿液BPA暴露水平与其体格发育存在关联且有性别差异。BPA暴露水平与幼儿胸围呈正相关,其中与女童胸围呈正相关,而与男童各体格发育指标呈一定的非线性关系,中高水平BPA暴露会减缓体格�
[Background]Studies have shown that bisphenol A(BPA),a typical environmental endocrine disrupting chemical,may affect children’s growth and development.The stage of toddlerhood is critical for physical growth,which indicates that children in this period might be more susceptible to the potential risks of BPA exposure.[Objective]This study examines the BPA levels in urine of two-year-old children in Shandong Laizhou Bay Area,and to explore their relationships with children’s physical growth in early childhood.[Methods]A total of 219 two-year-old children who were followed up in Laizhou Wan Birth Cohort(LWBC)were finally enrolled.The BPA levels in children’s urine samples were detected;their growth indices including body length,body weight,head circumference,chest circumference were measured,and body mass index(BMI)was calculated;their mothers’demographic variables and prenatal health related factors and their basic information and dietary data were collected with a questionnaire.Overall and sex-stratified generalized linear models were used to analyze the associations between children’s BPA exposure quartiles(Q1-Q4)and physical growth.[Results]The median of children’s urinary BPA concentration was 0.26μg·L^-1 or 1.07μg·g^-1(creatinine-adjusted).According to the generalized linear models,children’s BPA exposure levels were positively associated with their chest circumference(b=0.152,95%CI:0.028-0.275,Ptrend=0.016).Compared with the Q1 group,children’s body length and weight decreased significantly of the Q2 and Q3 groups(P<0.05).The length and weight of the Q2 group decreased(95%CI)by 1.29(2.25-0.32)cm and 0.49(0.94-0.03)kg,and those of the Q3 group decreased(95%CI)by 1.32(2.30-0.35)cm and 0.49(0.95-0.03)kg,respectively,even though the two variables showed variability with insignificant trend(Ptrend>0.05).No significant changes were found in other physical growth indicators.Among boys,compared with the Q1 group,the body length,weight,and BMI decreased significantly of the Q2 group(P<0.05),and al
作者
吕铖
余晋霞
卢婍
高宇
王彩凤
田英
LU Cheng;YU Jin-xia;LU Qi;GAO Yu;WANG Cai-feng;TIAN Ying(Department of Environmental Health,School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;School of Nursing,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;MOE-Shanghai Key Laboratory of Children's Environmental Health,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China)
出处
《环境与职业医学》
CAS
CSCD
北大核心
2020年第11期1050-1056,共7页
Journal of Environmental and Occupational Medicine
基金
国家自然科学基金青年项目(81803247)
国家自然科学基金面上项目(81872629)。
关键词
双酚A
2岁
幼儿
体格发育
内分泌干扰
bisphenol A
two years old
child
physical growth
endocrine disruption
