摘要
[背景]多溴二苯醚(PBDEs)是一种新型内分泌干扰物,在我国各地区的人群样本中均有检出。近年来有国外研究提示孕妇孕期PBDEs暴露对儿童发育可能存在不良影响,然而目前研究较少,结论尚不一致。[目的]了解我国PBDEs生产工业区的孕妇体内PBDEs暴露水平,并进一步分析孕期母血PBDEs暴露对8岁儿童生长发育的影响。[方法]研究对象来源于山东莱州湾出生队列(LWBC),该队列于2010年9月—2013年12月招募符合标准的待产孕妇及其新生儿。纳入121对符合标准的孕妇及其子代(2019年7—9月随访期间满8岁者),收集孕晚期孕妇血样本,采用气相色谱-负化学电离源-质谱检测孕期母血中8种PBDEs(BDE-28、BDE-47、BDE-85、BDE-99、BDE-100、BDE-153、BDE-154、BDE-183)水平;并将检出率>85%的5种PBDE同系物(BDE-28、BDE-47、BDE-99、BDE-100、BDE-153)水平之和作为Σ5PBDEs。于2019年7—9月随访8岁儿童,测量其身高、体重、腰围、体脂百分比,计算体重指数(BMI)。采用多元线性回归分析孕晚期母血PBDEs暴露水平与8岁儿童生长发育的关系。[结果]所有血清样本均可检测到PBDEs,且上述8种PBDEs同系物都有不同程度的检出,其中BDE-153、BDE-99的检出率最高,皆为95.87%,其质量分数(后称:水平)的中位数M及第25、75百分位数(P25,P75)分别为4.86(2.97,9.43)、3.54(2.16,5.35)ng·g^-1。儿童年龄为(8.14±0.47)岁。孕期母血BDE-85、BDE-99水平与8岁儿童体重呈正相关,回归系数b及其95%可信区间(CI)分别为8.63(0.95~16.30)、8.50(0.06~16.94)。BDE-47、BDE-85、BDE-99、BDE-153及Σ5PBDEs水平与8岁儿童身高呈正相关,其b(95%CI)分别为7.79(1.74~13.85)、6.12(0.01~12.24)、9.69(3.17~16.21)、6.75(0.21~13.29)、12.30(4.26~20.34)。BDE-85水平与8岁儿童腰围呈正相关,b(95%CI)为12.94(3.70~22.19)。进一步性别分层后发现:在男孩中,BDE-47、BDE-99、BDE-100、Σ5PBDEs水平与身高呈正相关,BDE-85水平与腰围呈正相关,均P<0.0
[Background]Polybrominated diphenyl ethers(PBDEs)are a new class of endocrine disruptors and have been detected in various types of human biological samples across China.Recently,prenatal exposure to PBDEs has been associated with child growth deviation.However,the quantity of such studies is limited and conclusions are inconsistent.[Objective]The study is conducted to detect exposure levels of PBDEs in pregnant women in PBDE production areas and examine the potential association between PBDEs exposure in pregnancy and child growth at 8 years of age.[Methods]The study included 121 mother-child pairs in Laizhou Wan Birth Cohort(LWBC),a cohort enrolled form September 2010 through December 2013 in Shandong,China.Serum samples were collected in the third trimester.Concentrations of PBDEs(BDE-28,BDE-47,BDE-85,BDE-99,BDE-100,BDE-153,BDE-154,BDE-183)in the samples were measured by gas chromatography-electron capture negative ion-mass spectrometry,and the concentration ofΣ5PBDEs was calculated(sum of five PBDEs of detection rates>85%:BDE-28,BDE-47,BDE-99,BDE-100,and BDE-153).Child height,weight,waist circumference,and body fat percentage were measured and body mass index(BMI)was calculated at follow-up visits during July to September 2019.The association between PBDEs exposure levels in late pregnancy and child growth at 8 years of age were quantified by multiple linear regression models.[Results]The PBDEs congeners were detected in all maternal serum samples to varying degrees.The detection frequencies of BDE-153 and BDE-99 were both 95.87%,which were the highest among the congeners,and the medians(P25,P75)were 4.86(2.97,9.43)and 3.54(2.16,5.35)ng·g^-1,respectively.The mean child age was(8.14±0.47)years.Maternal serum BDE-85 and BDE-99 concentrations were positively associated with child weight,and the regression coefficient b and 95%confidence interval(CI)were 8.63(0.95-16.30)and 8.50(0.06-16.94)respectively.Maternal serum BDE-47,BDE-85,BDE-99,BDE-153,Σ5PBDEs concentrations were positively associated with child hei
作者
潘承谕
卢婍
姚谦
田英
高宇
PAN Cheng-yu;LU Qi;YAO Qian;TIAN Ying;GAO Yu(Department of Environmental Health,School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;M0E-Shanghai Key Laboratory of Children's Environmental Health,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China)
出处
《环境与职业医学》
CAS
CSCD
北大核心
2020年第11期1042-1049,共8页
Journal of Environmental and Occupational Medicine
基金
国家自然科学基金项目(41991314,81773387,81630085)。
关键词
多溴二苯醚
8岁儿童
生长发育
性别差异
polybrominated diphenyl ethers
8-year-old child
growth and development
sex-specific association
