摘要
目的:探讨支气管哮喘(BA)急性发作患者血清氨基末端脑钠肽前体(NT-pro BNP)水平与肺栓塞的关系。方法:抽取2018年10月至2019年12月河南省神火集团职工总医院收治的78例BA急性发作患者为研究对象,根据肺栓塞诊断标准评估患者肺栓塞发生情况并将患者分为肺栓塞组(15例)和无肺栓塞组(63例);设计一般资料调查问卷,询问并详细记录患者的基线资料情况,记录并比较两组基线资料,检测并比较两组实验室相关指标水平,重点比较NT-proBNP水平,分析NT-pro BNP与BA急性发作患者肺栓塞的关系。结果:78例BA急性发作患者15例发生肺栓塞,发生率为19.23%;肺栓塞组血清肌钙蛋白T(TnT)、NT-pro BNP水平高于无肺栓塞组(P<0.05),其他基线资料组间比较差异未见统计学意义(P>0.05);经单项Logistic回归分析并建立多元回归模型,结果显示,血清TnT、NT-pro BNP过表达均可能是BA急性发作患者肺栓塞发生的影响因素(OR>1,P<0.05);绘制受试者工作特征曲线,结果显示,当血清NT-pro BNP cut-off值取116.675 pg/ml时,可获得肺栓塞最佳预测价值,受试者工作特征曲线下面积为0.913,有较高预测价值,且随着血清NT-pro BNP水平升高患者肺栓塞风险升高。结论:BA急性发作患者有较高的肺栓塞风险,可能与患者NT-proBNP过表达有关,未来可考虑检测血清NT-proBNP水平变化,以评估BA急性发作患者肺栓塞风险,或可能成为未来早期预防肺栓塞的新方向。
Objective To investigate the relationship between serum N terminal pro B type natriuretic peptide(NT-pro BNP)and pulmonary embolism in patients with acute bronchial asthma(BA).Methods A total of 78 patients with acute attack of BA treated in General Staff Hospital of Shenhuo Group from October 2018 to December 2019 were selected as the research objects.According to the diagnostic criteria of pulmonary embolism,the patients were divided into pulmonary embolism group(15 cases)and non pulmonary embolism group(63 cases).The general data questionnaire was designed to inquire and record the baseline data of patients in detail,the baseline data of the two groups were recorded and compared,the relevant laboratory indicators of the two groups were detected and compared,the comparison of NT proBNP level were,and focused on the relationship between NT Pro BNP and pulmonary embolism in patients with BA acute attack were analyzed.Results Among the 78 patients with acute attack of BA,15 cases had pulmonary embolism,the incidence was 19.23%;the levels of serum troponin T(TnT)and NT-pro BNP in the pulmonary embolism group were higher than those in the non-pulmonary embolism group(P<0.05),there was no significant difference in other baseline data between groups(P>0.05);after a single logistic regression analysis and a multiple regression model,the results showed that the overexpression of serum TnT and NT-pro BNP might be the influencing factors of the occurrence of pulmonary embolism in patients with acute attack of BA(OR>1,P<0.05);the receiver operating characteristic curve was drawing,and the results showed that when the serum NT-pro BNP cut-off value was 116.675 pg/ml,the best predictive value of pulmonary embolism could be obtained and the area under the receiver operating characteristic curve was 0.913,which had high predictive value,and the risk of pulmonary embolism was increased with the increase of serum NT-pro BNP level.Conclusions Patients with acute attacks of BA have a higher risk of pulmonary embolism,which may be
作者
张丽
Zhang Li(Department of Respiratory Medicine,General Staff Hospital of Shenhuo Group,Shangqiu 476600,China)
出处
《中国实用医刊》
2020年第22期64-68,共5页
Chinese Journal of Practical Medicine
关键词
氨基末端脑钠肽前体
支气管哮喘
肺栓塞
N terminal pro B type natriuretic peptide
Bronchial asthma
Pulmonary embolism
