摘要
目的探讨双源CT双能量碘图成像评估非小细胞肺癌放化疗效果的临床价值。方法收集广东省汕头市中心医院2018年10月至2021年10月79例经病理证实非小细胞肺癌患者。所有患者均放化疗前1周内及放化疗后第5周行双源CT双能量扫描,将第5周复查结果根据RECIST实体瘤标准分为治疗无效组和治疗有效组,记录两组治疗前后病灶动脉期病灶内碘覆盖值(CTA)、静脉期病灶内碘覆盖值(CTV)、动脉期标准化碘浓度(NIC_(AP))、静脉期标准化碘浓度(NIC_(VP))变化值。结果入组患者中治疗有效组为47例,治疗无效组为32例。治疗后,有效组CTA、CTV、NIC_(AP)、NIC_(VP)低于治疗前,且各指标低于无效组,差异有统计学意义(P<0.05)。有效组NIC_(AP)、CTA、NIC_(VP)、病灶最大径变化率高于无效组,差异有统计学意义(P<0.05)。病灶最大径变化率与CTA、NIC_(AP)、CTV、NIC_(VP)变化率呈正相关(r>0,P<0.05)。放化疗后,CTA、NIC_(AP)变化率评估NSCLC疗效的ROC曲线面积分别为0.817、0.882。结论双能量CT碘图成像可以预测非小细胞肺癌放化疗效果,为临床精准治疗提供参考依据。
Objective To investigate the clinical value of dual-source CT dual-energy iodography imaging to assess the efficacy of radiotherapy for non-small cell lung cancer.Methods Seventy-nine patients with pathologically confirmed non-small cell lung cancer from October 2018 to October 2021 were collected from Shantou Central Hospital.All patients underwent dual-source CT dual-energy scans within a week before radiotherapy and at five weeks after radiotherapy.The results of five weeks review were divided into treatment-ineffective and treatment-effective groups according to the RECIST solid tumor criteria,and the change values of clinical target arteries(CTA),clinical target venous(CTV),normalized iodine concentration in the arterial phase(NIC_(AP)),normalized iodine concentration in the arterial venous phase(NIC_(VP))of lesions before and after treatment were recorded in both groups.Results The number of patients enrolled was 47 in the treatment effective group and 32 in the treatment ineffective group.After treatment,CTA,CTV,NIC_(AP),and NIC_(VP) in the effective group were lower than before treatment,and each indexs were lower than those in the ineffective group,and the differences were statistically significant(P<0.05).The rate of change of NIC_(AP),CTA,NIC_(VP),and maximum diameter of lesion in the effective group were higher than those in the ineffective group,and the differences were statistically significant(P<0.05).The rate of change of the maximum diameter of the lesion was positively correlated with the rate of change of CTA,NIC_(AP),CTV,and NIC_(VP)(r>0,P<0.05).After radiotherapy,the ROC curve areas of CTA and NIC_(AP) change rates to assess the efficacy of NSCLC were 0.817 and 0.882,respectively.Conclusion Dual-energy CT iodography imaging can predict the therapeutic effect of radiotherapy for non-small cell lung cancer and provide a reference basis for precise clinical treatment.
作者
汪丹凤
林黛英
肖健宁
张晓琴
庄荞玮
胡泽桓
WANG Danfeng;LIN Daiying;XIAO Jianning;ZHANG Xiaoqin;ZHUANG Qiaowei;HU Zehuan(Department of Radiology,Shantou Central Hospital,Guangdong Province,Shantou 515041,China)
出处
《中国医药导报》
CAS
2022年第32期22-25,共4页
China Medical Herald
基金
广东省科技创新战略专项资金项目(汕府科〔2018〕157号-27)。
关键词
非小细胞肺癌
放射治疗
化学治疗
Non-small cell lung cancer
Radiotherapy
Chemotherapy
