摘要
肝细胞肝癌(HCC)是世界上常见的消化道恶性肿瘤之一,严重地威胁人类的生命安全。目前主要的治疗手段是手术切除、动脉栓塞化疗或等全身化疗,但效果均不佳。免疫治疗越来越受到研究者的关注。调节性B细胞(regulatory B cells,Bregs)是一类通过分泌白介素-10(IL-10)、转化生长因子-β(TGF-β)等细胞因子在自身免疫性疾病、肿瘤疾病及感染性疾病中发挥免疫抑制作用的B淋巴细胞群。其中,CD19CD24hiCD38hiB细胞是一种相当重要的亚型,在肿瘤免疫方面起着负性调节效应。本文就HCC与Bregs的相关性作一综述。
Hepatocellular carcinoma(HHC)is one of the most common malignant tumors of digestive tract in the world,which is a great threat to human life.At present,the main treatment methods are surgical resection,arterial chemoembolization or systemic chemotherapy,but the effect of treatments is not good.Immunotherapy has been getting more and more attention from researchers.Regulatory B cells(Bregs)are a group of B lymphocytes that play an immunosuppressive role in autoimmune diseases,tumor diseases,and infectious diseases by secreting cytokines such as interleukin-10(IL-10)and transforming growth factor-β(TGF-β).Among them,CD19CD24hiCD38hiB cells are one of the important subtypes,which play a negative regulatory effect on tumor immunity.This paper reviewed the correlation between HCC and Bregs.
作者
李龙飞(综述)
官成浓(审校)
LI Long-fei;GUAN Cheng-nong(Guangdong Medical University,Zhanjiang 524001,Guangdong,CHINA)
出处
《海南医学》
CAS
2020年第21期2804-2807,共4页
Hainan Medical Journal
