摘要
目的探讨采用定喘汤联合布地奈德治疗痰热蕴肺型哮喘的疗效及对肺功能的影响。方法选取2018年9月—2019年5月期间江苏省第二中医院呼吸科收治的痰热蕴肺型哮喘患者75例,随机分为对照组37例,治疗组38例。两组均基于临床症状给予解痉平喘,通氧等基本治疗,并给予优质护理。对照组采用布地奈德进行治疗,治疗组采用定喘汤联合布地奈德进行治疗,两组患者均接受治疗2周。治疗后,观察两组临床治疗疗效;观察治疗前后两组炎症因子水平及肺功能变化情况;观察治疗期间两组不良反应发生情况;治疗后3个月随访观察两组复发情况。结果治疗后治疗组总有效率92.11%(35/38)高于对照组总有效率81.08%(30/37),两组比较差异有统计学意义(P<0.05)。治疗后两组哮喘患者IL-6、CRP、PCT指标均较治疗前下降(P<0.05),且治疗组IL-6、CRP、PCT指标均低于对照组,差异有统计学意义(P<0.05)。治疗后两组哮喘患者FEV1、PEF、MMFR、FEV1/FVC水平指标均较治疗前上升(P<0.05),且治疗组FEV1、PEF、MMFR、FEV1/FVC水平指标均高于对照组,差异有统计学意义(P<0.05)。治疗期间对照组不良反应发生率16.22%(6/37),治疗组不良反应发生率18.42%(7/38),两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗后3个月随访,对照组复发率18.92%(7/37),治疗组复发率10.53%(4/38),两组复发率比较,差异有统计学意义(P<0.05)。结论定喘汤联合布地奈德治疗痰热蕴肺型支气管哮喘,疗效显著,可以改善炎症因子水平及肺功能,降低复发率,且未明显增加不良反应发生率,药物安全。
Objective To study the effect of Dingchuan Decoction combined with budesonide in the treatment of phlegm heat accumulation type asthma and influence on lung function.Methods 75 asthma of phlegm heat accumulation type patients treated in our hospital were selected from September 2018 to May 2019,and divided into the control group(n=37)and the treatment group(n=38)randomly.All the patients were given basic treatments such as anti-spasm,oxygen and other basic treatment based on clinical symptoms,and given high-quality care.On this basis,the control group was treated with budesonide,and the treatment group was treated by Dingchuan Decoction combine with budesonide,treated for 2 weeks.After treatment,two groups of therapeutic efficacy were observed.Inflammatory factor levels and lung function were observed before and after treatment.Two groups of adverse reactions were observed during treatment.The recurrence rate of two groups wer observed after treatment follow-up 3 months.Results After treatment,the total effective rate of the treatment group was 92.11%(35/38)higher than the total effective rate of the control group 81.08%(30/37).The difference between the two groups was statistically significant(P<0.05).After treatment,the IL-6,CRP and PCT indexes of the two groups of asthma patients were lower than before treatment(P<0.05),and the IL-6,CRP and PCT indexes of the treatment group were lower than those of the control group,the difference was statistically significant(P<0.05).After treatment,the FEV1,PEF,MMFR,FEV1/FVC level indicators of the two groups of asthma patients increased compared to before treatment(P<0.05),and the FEV1,PEF,MMFR,FEV1/FVC level indicators of the treatment group were higher than those of the control group,and there were differences Statistically significant(P<0.05).During the treatment period,the incidence of adverse reactions in the control group was 16.22%(6/37),and the incidence of adverse reactions in the treatment group was 18.42%(7/38).There was no significant difference in the incidenc
作者
张玲
刘梦云
ZHANG Lin;LIU Meng-yun(Department of Respiratory Medicine,Second Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing Jiangsu 210029;Department of Respiratory Medicine,Second Hospital of Jiangsu Province,Nanjing Jiangsu 210029)
出处
《世界中西医结合杂志》
2020年第9期1692-1695,共4页
World Journal of Integrated Traditional and Western Medicine
基金
江苏省中医药管理局科技项目(LZ17035)。
关键词
痰热蕴肺型哮喘
定喘汤
布地奈德
肺功能
Phlegm Heat Accumulation Type Asthma
Dingchuan Decoction
Budesonide
Lung Function
