摘要
目的探究钆塞酸二钠T1 mapping参数和细胞外容积(extracellular volume fraction,ECV)值定量评估兔肝纤维化(hepatic fibrosis,HF)的价值。材料与方法将100只新西兰大白兔随机分为HF组(n=80)和正常对照组(n=20),HF组皮下注射50%四氯化碳油溶液,正常对照组仅皮下注射生理盐水。MRI扫描进行T1 mapping成像后依据Metavir方法进行肝脏病理学分期。采用Spearmann方法分析T1 mapping(T1native、T110 min、T120 min)和ECV(ECV10 min和ECV20 min)定量参数值与HF进展的相关性,并应用ROC曲线评价定量参数值鉴别诊断HF分期的价值。结果F0、F1、F2、F3、F4期分别有14、19、15、19、18只。T1native、T110 min、T120 min、ECV10 min和ECV20 min随着HF进展均呈正相关趋势(r=0.685、0.428、0.818、0.278、0.766,P<0.001)。T120 min鉴别诊断≥F1、≥F2、≥F3、≥F4价值较其他参数值高,AUC值分别为0.90、0.93、0.93、0.92。结论T1 mapping和ECV参数值与HF进展密切相关,可作为定量评估HF分期的有效影像学方法。
Objective:To explore parameters obtained by Gd-EOB-DTPA T1 mapping and extracellular volume fraction in evaluating hepatic fibrosis(HF)in a rabbit model.Materials and Methods:One hundred rabbits were randomly divided into two groups:the HF group(n=80)and the control group(n=20).The HF model was established by carbon tetrachloride(CCl4)in our experiments,whereas control rabbits received a subcutaneous injection of normal saline.After completing T1 mapping imaging,rabbits underwent pathological examination to determine the HF stage using the metavir classification system.Then,quantitative parameters including T1native,T110 min,T120 min,ECV10 min and ECV20 min were measured and compared among the different HF stages using spearman correlation coefficients and receiver operating characteristic curve.Results:In all,14,19,15,19,18 rabbits had stage F0,F1,F2,F3 and F4,respectively,were included in this study.T1native(r=0.685),T110 min(r=0.428),T120 min(r=0.818),ECV10 min(r=0.278),and ECV20 min(r=0.766),increased with HF stage progression(P<0.001).The AUC of T120 min was higher than that of other quantitative parameters,with an AUC of 0.90,0.93,0.93 and 0.92 for staging≥F1,≥F2,≥F3,≥F4,respectively.Conclusions:T1 mapping parameters and ECV fraction are closely associated with HF progression,indicating that this may be a promising method for quantitatively differentiating HF.
作者
朱祖辉
邢伟
刘海峰
王晴
杜亚楠
李宇峰
张记磊
ZHU Zuhui;XING Wei;LIU Haifeng;WANG Qing;DU Ya’nan;LI Yufeng;ZHANG Jilei(Department of Radiology,third Affiliated Hospital of Soochow University&Changzhou First People's Hospital,Changzhou 213003,China;Department of Radiology,Changzhou First People's Hospital,Lanzhou 730000,China;Philips Healthcare,Shanghai 200072,China)
出处
《磁共振成像》
CAS
2020年第10期890-895,共6页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金(编号:81771798)
兰州大学中央高校基本科研业务费专项资金(编号:lzujbky-2019-cd04)。
