摘要
目的研究补充性肠外营养对食管癌术前系统免疫炎症指数及术后预后营养指数的影响。方法前瞻性选取2017年2月至2019年12月上海市静安区闸北中心医院收治的90例食管癌患者,采用随机数字表法分为实验组(n=46)和对照组(n=44)。实验组在对照组的基础上给予补充性肠外营养治疗,对照组给予常规治疗。比较两组患者治疗前、治疗后1 d、治疗后7 d系统免疫炎症指数(SII)、预后营养指数(PIN)、疼痛程度、生活质量。比较两组患者治疗后所引起的不良反应。结果治疗后1 d和治疗后7 d,实验组SII为442.12±20.56、413.56±20.41,显著低于对照组501.56±20.54、486.21±20.54,差异有统计学意义(P<0.05)。治疗后7 d,实验组PIN 48.56±4.41显著高于对照组38.21±4.34,差异有统计学意义(P<0.05)。治疗后7 d,实验组视觉模拟评分法(VAS)评分为(1.55±0.45)分,显著低于对照组(3.45±0.45)分,差异有统计学意义(P<0.05)。实验组生活质量简表(SAF-36)评分为(91.89±5.61)分,显著高于对照组(73.16±5.66)分,差异有统计学意义(P<0.05)。治疗后,实验组不良反应发生率2.73%(1/46)显著低于对照组15.90%(7/44),差异有统计学意义(P<0.05)。结论补充性肠外营养可以有效降低患者术前较高的系统免疫炎症指标,同时可以明显提高患者术后预后营养指数,降低患者疼痛程度,改善生活质量,同时减少并发症的发生。
Objective To study the effects of supplemental parenteral nutrition on the preoperative systemic immune inflammation index andpostoperative prognostic nutrition index in esophageal cancer.Methods Ninety patients with esophageal cancer admitted to Zhabei Central Hospital,Jing'an District from February 2017 to December 2019 were enrolled and divided into the experimental group(n=46)and the control group(n=44)by random number table method.The experimental group received supplemental parenteral nutrition on the basis of the control group,and the control group received conventional treatment.The systemic immune-inflammation index(SII)and prognostic nutrition index(PNI)1 and 7 days before and after treatment;the pain level and quality of life after 7 days of treatment;the adverse reactions aftertreatment were compared between the two groups of patients.Results After 1 and 7 days of treatment,the SII of the experimental group was 442.12±20.56,413.56±20.41,significantly lower than that of the control group 501.56±20.54,486.21±20.54,the differences were statistically significant(P<0.05).After 7 days of treatment,the PNI of the experimental group was 48.56±4.41,significantly higher than that of the control group 38.21±4.34,the difference was statistically significant(P<0.05).After 7 days of treatment,the visual analogue scale(VAS)score of the experimental group was(1.55±0.45)scores,significantly lower than that of the control group(3.45±0.45)scores,the difference was statistically significant(P<0.05).The score of the MOS item short from health survey(SF-36)was(91.89±5.61)scores,significantly higher than that of the control group(73.16±5.66)scores,the difference was statistically significant(P<0.05).Aftertreatment,the incidence of adverse reactions in the experimental group was 2.73%(1/46),significantly lower than that in the control group 15.90%(7/44),the difference was statistically significant(P<0.05).Conclusion Supplemental parenteral nutrition can effectively reduce the high systemic immune inflammation indic
作者
杨小娟
沈慧
袁伟
王静霞
王佳丽
王海
YANG Xiao-juan;SHEN Hui;YUAN Wei(Department of Marine Medicine,Naval Medical University,Ship Hygiene Department,Shanghai 200070,China;Department of Nutrition,Zhabei Central Hospital,Jing'an District,Shanghai 200070,China)
出处
《临床和实验医学杂志》
2020年第20期2202-2205,共4页
Journal of Clinical and Experimental Medicine
基金
上海市静安区医学科研课题项目(编号:2020YL01)
上海市自然科学基金项目(编号:19ZR1469700)。
关键词
食管癌
补充性肠外营养
系统免疫炎症指数
营养指数
Esophageal cancer
Supplemental parenteral nutrition
Systemic immune inflammation index
Nutrition index
