摘要
目的探讨补充性肠外营养联合肠内营养对鼻咽癌住院患者临床结局的影响。方法选取2017年1月至2019年1月间延安市人民医院收治的120例鼻咽癌住院患者,采用随机数字表法分为试验组和对照组,每组60例。两组患者均行根治性调强放疗,对照组患者治疗期间采用补充性肠外营养支持,试验组在对照组基础上加用肠内营养支持,比较两组患者的临床结局。结果试验组患者总有效率为83.3%,高于对照组的53.3%,差异有统计学意义(P<0.05)。试验组患者消化道反应、口腔溃疡、肝肾异常和血小板减少等不良反应发生率均低于对照组,差异均有统计学意义(均P<0.05)。试验组患者治疗第1周与第4周的营养不良发生率分别为1.7%(1例)和5.0%(3例),均低于对照组的13.3%(8例)和18.3%(11例),差异均有统计学意义(均P<0.05)。试验组患者躯体功能、心理功能、社会功能、共性症状与特异模块等生活质量评分均高于对照组,差异均有统计学意义(均P<0.05)。结论补充性肠外营养联合肠内营养支持能改善鼻咽癌住院患者的临床结局,减少不良反应与营养不良发生情况,提高治疗效果与生活质量。
Objective To investigate the effects of supplementary parenteral nutrition combined with enteral nutrition on clinical outcomes in hospitalized patients with nasopharyngeal carcinoma.Methods From January 2017 to January 2019,120 patients with nasopharyngeal carcinoma who admitted to Yanan People’s Hospital were selected and were divided into an experimental group and a control group with 60 patients in each group.All patients underwent radicalized radiotherapy.The experimental group received enteral nutrition support besides the parenteral nutrition and the control group received supplementary parenteral nutrition during the treatment period.The clinical outcomes were compared between the two groups.Results The overall efficacy rate was 83.3%in the experimental group,which were significantly higher than 53.3%of the control grou(P<0.05).The incidences of adverse reactions such as digestive tract reaction,oral ulcer,liver and kidney abnormality and thrombocytopenia were significantly lower in the experimental group than in the control group(all P<0.05).The incidences of malnutrition at 1 week and 4 week was 1.7%(1 patient)and 5.0%(3 patient),respectively in the experimental group,which were significantly lower than 13.3%(8 patients)and 18.3%(11 patients)of the control group(all P<0.05).After the treatment,scores of quality of life including psychological function,social function,common symptoms and specific modules were significantly higher in the experimental group than in the control group(all P<0.05).Conclusion Supplementary parenteral nutrition combined with enteral nutrition could improve the clinical outcomes,reduce the incidence of adverse reactions and malnutrition,and improve the treatment efficacy and quality of life in hospitalized patients with nasopharyngeal carcinoma.
作者
郭延玲
贺婧
张福林
李静
GUO Yan-ling;HE Jing;ZHANG Fu-lin;LI Jing(Department of Nutrition,Yanan People's Hospital,Yanan 716000,China;Prevention and Control Center,Yanan 716000,China;Department of Hematology and Oncology,Yanan People's Hospital,Yanan 716000,China)
出处
《中国肿瘤临床与康复》
2019年第11期1184-1187,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
肠内营养
肠外营养
鼻咽肿瘤
不良反应
生活质量
Enteral nutrition
Parenteral nutrition
Nasopharyngeal neoplasms
Adverse reactions
Quality of life
