摘要
目的探究小续命汤加减联合体外冲击波碎石(ESWL)治疗肾结石的效果及对结石排出率的影响。方法选取本院泌尿外科2018年4月至2020年4月收治的76例肾结石患者,按照随机数字表法分为观察组与对照组各38例。对照组采用ESWL治疗,观察组联合小续命汤加减。比较两组治疗疗效、结石排出率、排净时间及治疗前后的尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、β2微球蛋白(β2-MG)、半胱氨酸蛋白酶抑制剂(Cys-C)水平,记录并发症发生率。结果观察组疗效总有效率94.74%,显著高于对照组78.95%(P<0.05);观察组结石排出率显著高于对照组,结石排净时间显著短于对照组(均P<0.05);治疗后观察组NGAL、β2-MG、Cys-C指标均显著低于对照组(均P<0.05);观察组并发症发生率5.26%显著低于对照组26.32%(P<0.05)。结论肾结石患者采用小续命汤加减联合ESWL治疗可明显提高治疗疗效和结石排出率,尽早排尽结石,并下调NGAL、β2-MG、Cys-C指标,发挥一定肾脏保护作用,从而降低并发症发生风险。
Objective To explore the effects of modified Xiaoxuming decoction combined with extracorporeal shock wave lithotripsy(ESWL)in the treatment of kidney stones and its influence on stone discharge rate.Methods Seventy-six patients with kidney stones who were admitted and treated in Urinary Surgery of our hospital between April 2018 and April 2020 were enrolled.They were divided into observation group and control group by the random number table method,38 cases in each group.The patients in the control group were treated with ESWL,and the patients in the observation group were treated with ESWL combined with modified Xiaoxuming decoction.The curative effect,stone discharge rate,clearance time,urine neutrophil gelatinase-associated lipocalin(NGAL),β2 microglobulin(β2-MG),and Cystain C(Cys-C)levels were compared between the 2 groups.The incidence of complications was recorded.Results The total response rate in the observation group(94.74%)was significantly higher than 78.95%in the control group(P<0.05).The stone discharge rate in the observation group was significantly higher than that in the control group,and the clearance time was significantly shorter than that in the control group(both P<0.05).After treatment,NGAL,β2-MG,and Cys-C levels in the observation group were significantly lower than those in the control group(all P<0.05).The incidence of complications in the observation group(5.26%)was significantly lower than that in the control group(26.32%)(P<0.05).Conclusion Modified Xiaoxuming decoction combined with ESWL for treating kidney stones can significantly improve the curative effect and stone discharge rate,realizing stone clearance as early as possible.The treatment also can protect the kidney through regulating NGAL,β2-MG,and Cys-C,thus reducing the risk of complications.
作者
王博
Wang Bo(Urinary Surgery,Luoyang First People's Hospital,Luoyang 471002,China)
出处
《国际医药卫生导报》
2020年第19期2913-2916,共4页
International Medicine and Health Guidance News
关键词
小续命汤
体外冲击波碎石
肾结石
结石排出率
Xiaoxuming decoction
Extracorporeal shock wave lithotripsy(ESWL)
Kidney stone
Stone discharge rate
